5 citations
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May 2017 in “Journal of the European Academy of Dermatology and Venereology” The study found no significant difference in stress hormone levels between people with alopecia areata and healthy individuals, suggesting that the disease is not caused by an overactive stress response system.
August 2026 in “LUMEN ET VIRTUS” Low-dose oral minoxidil (LDOM) for androgenetic alopecia appears to have an acceptable cardiovascular safety profile in adults with stable hypertension or arrhythmias, based on a review of 20 studies. While LDOM generally caused small changes in blood pressure and heart rate, symptomatic hypotension and tachycardia were infrequent. However, the evidence is limited by retrospective designs and short follow-up periods. Rare cases of fluid retention or pericardial effusion necessitate clinical vigilance. Treatment should be individualized and coordinated with cardiovascular care, especially in patients with baseline instability or significant cardiovascular conditions.
6 citations
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May 2007 in “Forensic Science Medicine and Pathology” Minoxidil can make it hard to detect cocaine in hair tests.
83 citations
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December 2001 in “Journal of Investigative Dermatology” Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
13 citations
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December 2017 in “CNS Neuroscience & Therapeutics” Finasteride affects young male rats' brain function and behavior negatively.
Higher nitric oxide synthase levels in the scalp may influence hair loss in androgenetic alopecia.
354 citations
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August 1991 in “Molecular Endocrinology” Human adrenals and gonads have a unique enzyme for steroid hormone production.
4 citations
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December 2024 in “European Journal of Medicinal Chemistry” New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.
3 citations
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December 2024 in “Biomolecules & Therapeutics” Tanshinone compounds can help prevent hair loss caused by testosterone.
26 citations
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June 2003 in “PubMed” Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.
37 citations
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February 2005 in “Journal of Investigative Dermatology” Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.
March 2023 in “Clinical Toxicology” The PI's development is closely linked to skin and hair pigmentation in macaques.
1 citations
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August 2023 in “Andrology” Finasteride changes hormone levels and certain proteins in rats, but these effects can be reversed after stopping the drug.
December 2023 in “Toxicology communications” Minoxidil overdose caused severe low blood pressure, but the patient recovered with specific treatments.
2 citations
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August 2021 in “Journal of Clinical Psychopharmacology” An 8-year-old girl's eyebrow hair loss was linked to atomoxetine for ADHD but grew back after stopping the medication.
6 citations
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May 2022 in “Medicina-lithuania” IMA may indicate oxidative stress in skin and hair disorders, but more research is needed.
Male androgenetic alopecia (MAA) is a common, hereditary hair loss condition in men, linked to heart disease, and can be treated with minoxidil, finasteride, or hair transplantation.
18 citations
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July 2009 in “Drug Metabolism and Disposition” Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
Minoxidil overdose can cause serious side effects, and users should be educated on its safe use.
1′S-1′-Acetoxychavicol acetate may help treat hair loss by reducing oxidative stress.
32 citations
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December 1965 in “The Lancet” Argininosuccinic aciduria can cause hair loss.
55 citations
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March 1973 in “PubMed” Minoxidil is a new drug that lowers blood pressure.
115 citations
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March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” Key enzymes control androgen levels, affecting hormone activity and potential treatments.
April 2024 in “The Journal of urology/The journal of urology” SRD5A2 methylation in blood can predict how well someone will respond to finasteride treatment.
6 citations
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January 2016 in “Journal of Clinical and Diagnostic Research” Topical minoxidil might potentially cause vision problems, but more research is needed.
2 citations
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December 2013 in “Xenobiotica” Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.
135 citations
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March 2000 in “Journal of Biological Chemistry” Agouti and AGRP affect pigmentation and obesity, with implications for metabolic disorders.
1 citations
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January 1981 in “Elsevier eBooks” Melatonin stops melanin production after tyrosinase action, with cyclic GMP mimicking this effect.