124 citations
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August 1994 in “Journal of Investigative Dermatology” Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.
7 citations
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May 2021 in “EBioMedicine” Increased methylation of the Filip1l gene may contribute to aggressive skin cancer.
3 citations
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July 2017 in “Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model” Mouse hair follicle stem cells have a flexible chromatin state that supports skin health and hair growth.
April 2010 in “Cancer Research” CDK4 levels affect the number of hair follicle stem cells in mice.
January 2005 in “Enlighten: Publications (The University of Glasgow)” Melanocyte pathology requires keratinocyte hyperplasia and regulation dysfunction.
4 citations
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January 2025 in “Molecules and Cells” Use ethical and humane practices in mouse research.
July 2025 in “Journal of Investigative Dermatology” Researchers created long-lasting, diverse skin organoids from mouse hair follicle stem cells, useful for studying skin.
4 citations
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September 2024 in “Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics” 3D models and organoids improve liposarcoma research and therapy development.
82 citations
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March 2016 in “Autoimmunity reviews” Animal models have helped understand hair loss from alopecia areata and find new treatments.
55 citations
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February 2013 in “The Anatomical Record” Mouse nails are similar to human nails, making them useful for studying nail diseases.
31 citations
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January 2021 in “Experimental Dermatology” Skin organoids are a promising new model for studying human skin development and testing treatments.
14 citations
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May 2008 in “Journal of Visualized Experiments” Mouse epidermal neural crest stem cells can become various cell types and are easily obtained from hair follicles.
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May 2005 in “Experimental Dermatology” Two mouse mutations cause similar hair loss despite different skin changes.
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July 2024 in “Animals” A new depilation method using cold wax reduces injury and improves hair growth studies in mice.
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May 2022 in “Advanced therapeutics” A new microneedle system effectively delivers a vasodilator to hair follicles, promoting hair growth better than current treatments.
April 2018 in “Journal of Investigative Dermatology” Dsg1 is essential for maintaining a healthy skin barrier in mice.
15 citations
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June 2015 in “PLoS ONE” Thymosin beta-4 promotes hair growth in mice.
3 citations
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January 2011 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” Male mice have thicker skin, causing more light scattering than females.
Hair follicles influence blood vessels during hair growth, suggesting potential treatments for hair growth issues.
April 1981 in “Pediatric research” Copper treatments increase copper in all tissues, but brindled female mice accumulate much more copper in their kidneys without clinical effects, unlike brindled male mice where brain copper deficiency is clinically significant.
69 citations
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May 1997 in “Veterinary Pathology” The angora mouse mutation causes long hair and hair defects due to a gene deletion.
56 citations
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September 2010 in “Veterinary pathology” Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.
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May 1999 in “Journal of Investigative Dermatology” Alopecia areata is complex, with genetic and immune factors, and animal models are key for future treatment research.
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April 2024 in “Biology” Improving human hair follicle models is crucial for better hair loss treatments.
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October 2020 in “Journal of Pharmacology and Experimental Therapeutics” Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.
December 2024 in “Drug Discoveries & Therapeutics” Baricitinib-loaded EVs help hair regrowth in alopecia areata by reducing inflammation and promoting hair follicle regeneration.
June 2024 in “Frontiers in pharmacology” 2-deoxy-D-ribose gel may help regrow hair in cases of hair loss.
January 2017 in “Corpus Université Laval (Université Laval)” Dutasteride may protect brain cells in early Parkinson's, while progesterone helps neuron recovery.
40 citations
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July 1981 in “Journal of Neuropathology & Experimental Neurology” Copper injections improved symptoms and prevented brain damage in brindled mice.
23 citations
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January 1985 in “Journal of Neuropathology & Experimental Neurology” Cupric chloride treatment corrected abnormal Purkinje cell development in brindled mice.