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research Gain‐of‐function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

28 citations , November 2018 in “American Journal of Medical Genetics Part A”

ODC1 gene mutations cause a neurodevelopmental disorder with large head size, hair loss, and facial abnormalities.

research Comparative Studies on Polyamine Levels in Plasma and Urine of Androgenic Alopecia Patients Treated with Finasteride for a Period of Three Years

January 2020 in “International Journal of Applied Biology and P”

Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.

research Distribution of polyamines may be altered in different scalp regions of patients with hair loss

3 citations , July 2019 in “Experimental Dermatology”

Hair loss patients may have different polyamine levels in various scalp areas.

research Drug Repurposing Patent Applications July–September 2025

January 2025 in “Drug repurposing”

New drug uses show promise but need more research.

research Bachmann–Bupp syndrome and treatment

July 2023 in “Developmental medicine and child neurology/Developmental medicine & child neurology”

DFMO treatment improves hair growth, muscle tone, and development in Bachmann-Bupp syndrome patients.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

research Expanding the phenotype: Four new cases and hope for treatment in Bachmann‐Bupp syndrome

11 citations , September 2021 in “American Journal of Medical Genetics Part A”

Four new cases of Bachmann-Bupp syndrome suggest potential for targeted treatment.

research Pure linoleate deficiency in the rat: influence on growth, accumulation of n-6 polyunsaturates, and [1-14C]linoleate oxidation

109 citations , April 1997 in “Journal of Lipid Research”

Linoleate deficiency in rats reduces growth and n-6 polyunsaturate accumulation, causing mild symptoms.

research N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting

76 citations , June 2015 in “Journal of biomedical science”

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

research N-acetylcysteine in the treatment of trichotillomania

65 citations , January 2012 in “International Journal of Trichology”

N-acetylcysteine may help treat trichotillomania.

research Amphetamine and N-Acetylamphetamine Incorporation into Hair: An Investigation of the Potential Role of Drug Basicity in Hair Color Bias*

65 citations , May 2001 in “Journal of Analytical Toxicology”

Basic drugs like amphetamine are absorbed more in darker hair than lighter hair.

research Dendritic polyglycerol and N-isopropylacrylamide based thermoresponsive nanogels as smart carriers for controlled delivery of drugs through the hair follicle

62 citations , November 2016 in “Nanoscale”

Medium to larger nanogels effectively deliver drugs through hair follicles when heated.

research Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain

61 citations , September 2011 in “Pain”

PEA reduces pain by increasing neurosteroid synthesis in the spinal cord.

research Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

53 citations , November 2021 in “Molecular Human Reproduction”

N-acetylcysteine may help treat uterine and placental issues in PCOS.

research Trichotillomania: a good response to treatment with N-acetylcysteine

27 citations , August 2017 in “Anais Brasileiros de Dermatologia”

N-acetylcysteine effectively treats trichotillomania.

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

27 citations , July 2017 in “Scientific Reports”

N-WASP is essential for healthy skin and preventing inflammation.

An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess

research An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess

27 citations , December 2013 in “Endocrinology”

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

research N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

17 citations , December 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists found new, better-working inhibitors for a hormone-related enzyme.

research Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine

15 citations , December 2016 in “Advanced Pharmaceutical Bulletin”

The new cream with N-acetyl glucosamine didn't change skin color after 8 weeks.

research N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) Targets TRP-2 and Inhibits Melanogenesis and Melanoma Growth

15 citations , April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

A3B5 can reduce skin pigmentation and slow melanoma growth.

Anti-Inflammatory, Thrombolytic, and Hair-Growth Promoting Activity of the n-Hexane Fraction of the Methanol Extract of Leea Indica Leaves

research Anti-Inflammatory, Thrombolytic and Hair-Growth Promoting Activity of the n-Hexane Fraction of the Methanol Extract of Leea indica Leaves

13 citations , May 2021 in “Plants”

The leaf extract of Leea indica may reduce inflammation, dissolve blood clots, and promote hair growth.

research Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women

11 citations , June 2015 in “Scientific Reports”

The mtDNA N haplogroup is linked to a higher risk of late-onset lupus and specific symptoms in Han Chinese women.

research THE N- AND C-TERMINAL END GROUPS OF HAIR KERATIN

7 citations , January 1959 in “Canadian Journal of Chemistry”

Human and horse hair have similar end groups to wool and feathers.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Anti-Alopecia Characteristics of Ethanol Extract, n-Hexane, Ethyl acetate and Water Fractions of Malvaviscus arboreus Cav

4 citations , January 2018 in “Research journal of pharmacy and technology”

Wera leaf extract can help with hair growth.

research Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications

4 citations , December 2013 in “Acupuncture and related therapies”

N-acetyl-cysteine shows promise in treating various diseases and may improve skin and hair conditions, but more research is needed on dosages and long-term effects.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research Trichotillomania treated with n-acetylcysteine

3 citations , May 2018 in “Psychiatry and Clinical Psychopharmacology”

N-acetylcysteine may help treat trichotillomania.

research Studies on the efficacy of methyl esters of n-alkyl fatty acids as penetration enhancers

3 citations , September 1989 in “Journal of Investigative Dermatology”

Methyl caprate greatly increases drug absorption through the skin and is better than other enhancers.

research Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli

2 citations , May 2022 in “Research Square (Research Square)”

KGF-1 135 is a stable and effective alternative for treating oral mucositis.