12 citations
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April 1995 in “Journal of Medicinal Chemistry” The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
2 citations
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July 2021 in “UNC Libraries” Mutations at Val-889 and Arg-752 disrupt key interactions in androgen receptor dimerization.
4 citations
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August 2024 in “PLoS ONE” Both injectable contraceptives lower testosterone and SHBG levels, with NET-EN having a greater effect than DMPA-IM.
Nanostructured lipid carriers can improve androgenic alopecia treatment by reducing dutasteride dosage and maintaining its presence in hair follicles longer.
105 citations
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June 2010 in “The journal of sexual medicine” Testosterone undecanoate increases lean mass and causes various physical changes in female-to-male transsexuals.
7 citations
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July 1981 in “Clinical and Experimental Dermatology” The normalized androgen ratio can help manage conditions with excess androgen activity in women.
27 citations
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October 1945 in “Endocrinology” Synthetic hormone treatment reduces melanin and hair growth in rats.
1 citations
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December 2011 in “Arzneimittelforschung” CB-03-04 shows promise as a treatment for prostate issues due to its strong anti-androgen effects.
6 citations
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August 2020 in “International Research Journal on Advanced Science Hub” The niosomal gel effectively delivers testosterone through the skin with fewer side effects.
14 citations
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June 1982 in “Archives of Dermatology” A man had bad reactions to a hair loss treatment called DNCB.
63 citations
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January 2010 in “Frontiers in Aging Neuroscience” 3α-androstanediol helps reduce age-related cognitive and mood declines in male rats, unlike testosterone.
227 citations
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January 1998 in “Journal of biological chemistry/The Journal of biological chemistry” Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.
12 citations
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June 2019 in “Psychoneuroendocrinology” Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.
2 citations
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July 2020 in “Behavioural Brain Research” Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.
Neurosteroids help control dopamine responses in the brain.
December 2023 in “Biointerface Research in Applied Chemistry” Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.
164 citations
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January 2003 in “Drugs”
4 citations
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January 1998 in “Heterocycles” Researchers made two new compounds that could be used for medicine.
88 citations
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February 2008 in “Journal of Medicinal Chemistry” Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.
27 citations
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July 2008 in “The Journal of Steroid Biochemistry and Molecular Biology” The new compounds may be more effective and cheaper than current treatments for conditions like baldness.
16 citations
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October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology” Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
18 citations
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April 2009 in “Journal of Chromatography A” Detecting steroid esters in cattle hair is inconsistent and influenced by sampling factors.
57 citations
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April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology” Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.
8 citations
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April 1991 in “European journal of endocrinology” 3α-AdiolG is a good marker for androgen activity in women with excessive hair growth and decreases with anti-androgen treatment.
97 citations
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November 1986 in “Journal of Steroid Biochemistry” Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.
October 2024 in “International Journal of Pharmaceutics” Finasteride in lipid carriers improved hair growth in rats.
January 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity”
45 citations
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January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.