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Dopaminergic neurons in the gut have distinct subtypes, some releasing both dopamine and acetylcholine.

Targeting neurosteroids may help prevent drug relapse.

Dopaminergic neurons in the gut have diverse subtypes with different neurotransmitter contents.

EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.

AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.

DHT is needed for long-term depression, while E2 is needed for full long-term potentiation in male rat brains.

The compound GD-23 may reduce anxiety like diazepam by targeting the TSPO receptor.

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

Abnormal amino acid metabolism may worsen rosacea symptoms.

Endogenous neurosteroids may set a baseline mood.

Diabetic neuropathy in mice is linked to poor mitochondria function and lower brain hormone production.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Midazolam's antiseizure effects are mainly due to synaptic GABA-A receptors, not neurosteroids or extrasynaptic receptors.

Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.

Progesterone and its metabolites can prevent seizures without major side effects.

Newly made nicotinamide compounds could potentially treat cancer.

Pharmacophore models can predict liver toxicity and central nervous system toxicity, but they have limitations and specific requirements.

HDAC inhibitors help brain cells grow and improve brain function.

Estrogen and androgen signals control synaptic changes in rat brains.

Certain vitamins in wrong amounts, alcohol abuse, metals, and other toxins can cause serious brain and nerve damage.

Ethanol blocks memory formation in rats by enhancing certain brain chemicals.

Plant-based compounds show promise for treating neurodegenerative diseases but need more research.

2-DG reduces seizures by enhancing brain inhibition through specific receptor activation.

Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.

GD-23 reduces anxiety by relying on neurosteroid production.

Neurosteroids may help prevent seizures in epilepsy.

A compound named ZCZ90 can increase muscle spindle firing, potentially helping treat muscle spasms and hypertension.

PEA boosts allopregnanolone production and reduces oxidative stress in brain cells.

PEA reduces pain by increasing neurosteroid synthesis in the spinal cord.

Neurosteroids help protect the brain and improve behavior after a stroke in mice.