research The regenerative potential of skin and the immune system
The skin's immune system helps it regenerate and fight infections.
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research Reviewer #4 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
Sensory neuron remodeling and Merkel-cell changes in the skin happen independently.
research 0867 The role of schwann cell - macrophage interactions in keloid pathogenesis
Schwann cell and M2 macrophage interactions contribute to keloid growth by increasing matrix deposition.
research Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain
Neural stem cells use local feedback to maintain balance in the adult brain.
research Chronic overlapping pain conditions and nociplastic pain
Nociplastic pain is a complex, heritable trait with genetic links to chronic and neuropathic pain.
research Involvement of neurosteroids in the control of hypothalamic-pituitary-adrenal axis activity in pregnant sheep under basal and stressful conditions
Neurosteroids play a key role in controlling the brain-adrenal gland activity in pregnant sheep, both in normal and stressful situations.
research Neurosteroids on the Epilepsy Chessboard—Keeping Seizures in Check
Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.
research 461: THE PROFIBROGENIC ROLE OF NEUTROPHIL EXTRACELLULAR TRAPS IN STENOTIC CROHN'S DISEASE: A NEW ANTIFIBROTIC TARGET?
Targeting NETs may help reduce fibrosis in Crohn's disease.
research Reviewer #2 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
Sensory neurons and Merkel cells remodel at different rates during normal skin maintenance.
research Gut microbes and skin disease, gut-brain-skin axis: A review
Balancing gut microbes and managing stress can help improve skin conditions like eczema and acne.
research News updates
Early exposure to germs may protect against autoimmune diseases, lack of sex increases alcohol preference in fruit flies, a potential baldness treatment could involve blocking a specific receptor, skin memory cells help prevent re-infection, high-fat diets can affect brain cells related to weight, and the link between social status, stress, and heart disease in primates is unclear.
research Nerve cells and nervous systems: an introduction to neuroscience
Neurons and synapses are key to brain function and learning.
research Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes
Neurosteroids may help treat disorders with too much dopamine activity.
research Molecular crosstalk between lncRNA H19, miR-29a, and JAK2/STAT3 signaling in alopecia areata: a preliminary study
research New frontiers in human hair follicle (neuro‐)endocrinology
Human scalp hair follicles can produce and respond to several hormones, affecting hair growth and pigmentation.
research Nail Involvement inAutoimmune Bullous Disorders
The nail immune system is similar to hair but different from skin, with fewer immune markers.
research Pericyte Plasticity in the Brain
research Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling
Targeting Midkine can help reduce pain and itching in keloids.
research Relating neurosteroid modulation of inhibitory neurotransmission to behaviour
Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.
research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization
Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
research Effect of transcranial electrical stimulation on markers of immunosuppression in patients with COVID-19
Transcranial electrical stimulation may help reduce certain immune markers in COVID-19 patients.
research Montagna Symposium 2016—The Skin: Our Sensory Organ for Itch, Pain, Touch, and Pleasure
The symposium highlighted the skin's role in sensing itch, pain, touch, and pleasure, and discussed new research and techniques for understanding and treating these sensations.
research A bibliometric analysis of T cell and atherosclerosis
T cells and inflammation are crucial in atherosclerosis, with anti-inflammatory treatments showing promise.
research 0960 Evidence for resident memory T cells and necroptosis as drivers of fibrosis in eosinophilic fasciitis and morphea
Resident memory T cells and necroptosis may drive fibrosis in eosinophilic fasciitis and morphea.
research Corticotropin releasing hormone and the skin
CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.
research Dissecting the Roles of Innate Cells in the Skin and Intractable Skin Diseases
Hair follicles regulate immune cells in the skin, and disrupting certain pathways can lead to skin issues and infections.
research Chronic Overlapping Pain Conditions and Nociplastic Pain
Nociplastic type pain, common in Chronic Overlapping Pain Conditions, is a complex, heritable trait linked to 24 unique genetic factors and 127 genes, with potential shared mechanisms in cognitive, personality, and metabolic traits.
research Reviewer #3 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
Sensory neuron changes and Merkel-cell changes in the skin happen independently during normal skin maintenance.
research Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation
Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.
research Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game?
Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.