Nucleic Acid-Induced Chemokine Expression in Keratinocytes: Implications for Skin Inflammation

    November 2025 in “ PLoS ONE ”
    Judit Danis, E. Kelemen, Fanni Balogh, Kornélia Szabó, Gergely H. Fodor, Éva Ádám, Márta Széll
    TLDR Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.
    This study investigates the role of nucleic acids in inducing chemokine expression in human keratinocytes, which is relevant to skin diseases like psoriasis, atopic dermatitis, vitiligo, and alopecia areata. The researchers found that cytoplasmic nucleic acids significantly induce the expression of chemokines such as CCL2, CXCL10, and CX3CL1 through NF-κB activation. However, the specific pattern recognition receptors involved remain unidentified. Additionally, no alternative splicing of these chemokines was observed, indicating that other regulatory mechanisms might be at play in chemokine activity.
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