research Decision letter: The signaling lipid sphingosine 1-phosphate regulates mechanical pain
Sphingosine 1-phosphate helps control mechanical pain.
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120-150 / 1000+ resultsresearch Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects
Mesotherapy is a skin injection therapy used for pain and local conditions, with scientific support but needing more clinical trials.
research Precision medicine strategies for spinal degenerative diseases: Injectable biomaterials with in situ repair and regeneration
Injectable biomaterials show promise for treating spinal degeneration but need better design for effective use.
research Neurotrophins, nociceptors, and pain
Neurotrophins, especially NGF, are crucial for pain development and management.
research Dynamic immunomodulatory nanoarchitectonics: Rewiring tissue regenerative microenvironment via intelligent regulation
Nanotechnology can improve tissue healing by controlling immune responses.
research Refractory Trichodynia Treated Using Onabotulinumtoxin-A
Onabotulinumtoxin-A injections significantly improved scalp pain in a patient with trichodynia.
research Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice
AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.
research Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat
Finasteride reduces pain in male rats and works better with testosterone.
research The Role of Other Peripheral Nerve Blocks
Peripheral nerve blocks are a safe and effective way to treat various headaches and provide lasting pain relief.
research Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat
Finasteride boosts morphine's pain relief and prevents tolerance and withdrawal in rats.
research Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial
Memantine may slightly improve memory in people with Down syndrome, but more research is needed.
research Chronic Pelvic Neuralgia Following Finasteride Exposure: A Case Report Suggestive of Nociplastic Dominant Pain
Chronic pelvic pain after finasteride may need pain education and rehab, not just medical treatments.
research Finasteride, a 5α-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat
Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.
research Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
Multitarget drugs are needed to better treat complex diseases.
research Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation
Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.
research Mesenchymal stem cells and their secretome: a promising approach for Parkinson’s disease treatment
Mesenchymal stem cells show promise for treating Parkinson's disease by protecting and repairing brain cells.
research Drug Delivery Systems based on Microneedles for Dermatological Diseases and Aesthetic Enhancement
Microneedle patches improve drug delivery for skin treatments and cosmetic enhancements.
research Anti-nociceptive and anti-inflammatory properties of 5alpha-reductase inhibitor finasteride in experimental animals
Finasteride helps reduce pain and inflammation in animals.
research Human dermal fibroblast‐derived secretory proteins for regulating nerve restoration: A bioinformatic approach
Human dermal fibroblast proteins help restore nerves during healing.
research Pharmacovigilance-based drug repurposing: searching for putative drugs with hypohidrosis or anhidrosis adverse events for use against hyperhidrosis
Certain existing drugs, like glycopyrronium and botulinum toxin type A, may help treat excessive sweating.
research Role of Anticonvulsant and Antiepileptogenic Neurosteroids in the Pathophysiology and Treatment of Epilepsy
Neurosteroids show promise for treating epilepsy and more research is needed.
research GABAAreceptor modulation by neurosteroids in models of temporal lobe epilepsies
Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.
research Nanoemulgels: A new approach for the treatment of skin-related disorders
Nanoemulgels improve skin disorder treatment by delivering drugs more effectively and reducing application frequency.
research PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function
Euph E and Euri A from Euphorbia neriifolia help control inflammation and immune response in cells.
research 1495 Dimethyl fumarate ameliorates delayed wound healing due to IL-36Ra deficiency through inhibition of NET formation and oxidative stress
Dimethyl fumarate speeds up wound healing in IL-36Ra deficient mice by reducing NET formation and oxidative stress.
research اثر تستوسترون اگزوژن و داروی Finasteride بر بی دردی ناشی از مورفین در موش های سوری نر با استفاده از تست فرمالین
Testosterone reduces, while finasteride enhances, morphine's pain relief.
research Effects of Potassium Channel Modulators on the Responses of Mammalian Slowly Adapting Mechanoreceptors
Potassium channel modulators mostly increase the activity of rat whisker mechanoreceptors.
research Synaptic‐like vesicles and candidate transduction channels in mechanosensory terminals
SLVs help maintain muscle stretch sensitivity and could aid in treating hypertension and muscle spasticity.
research Secretome of Mesenchymal Stromal Cells as a Possible Innovative Therapeutic Tool in Facial Nerve Injury Treatment
The secretome from mesenchymal stromal cells shows promise for improving facial nerve injury treatment.
research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures
EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.