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Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

Enzyme activities do not cause early pubic hair in these girls.

Everyone has an immune response to PPD, but reactions differ, causing tolerance, mild inflammation, or allergy.

Alopecia areata may involve stress-related changes affecting hormone receptors, leading to reduced cortisol production.

Neuroendocrine paraneoplastic syndromes often show skin changes, helping early diagnosis and requiring a team approach for best care.

Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

A young woman's rare ovarian tumor was successfully removed, improving her hormonal symptoms.

The new method showed that endometriotic tissue has lower estrogen receptor levels but similar progesterone levels compared to normal endometrium, with both following a similar cycle.

Low-dose effects in rodent studies are hard to confirm due to confounding factors and control group variability.

Cyclophosphamide helped 59.4% of children with steroid-resistant nephrotic syndrome but caused side effects in 40.6%.

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Testing basal 17-HP levels is a good way to screen for nonclassic adrenal hyperplasia in women with high androgen levels.

Steroid hormones are vital for body functions and disease management.

A single steroid injection can cause serious side effects like Cushing Syndrome.

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

A woman's hair loss and other symptoms were due to a rare hormone deficiency treatable with steroids.

Early hormones shape sex-specific differences in rat glands.

Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.

Long-term antiandrogen use may increase aggressive prostate cancer risk.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Interface dermatitis is the most common skin change in drug-induced hypersensitivity syndrome.