research Visualization of individual cell division history in complex tissues
The tool iCOUNT helps understand how stem cells divide and affect tissue development and repair.
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870-900 / 1000+ resultsresearch Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis
Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.
research Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation
Mesenchymal MEIS2 is essential for whisker development without needing sensory nerves.
research Melanocytes and Vitiligo (and Hair Graying)
Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.
research Engineering immune-competent hair follicle microphysiological systems: from organoid assembly to dynamic immune modelling
This review discusses the advancement of hair follicle organoids towards immune-competent hair follicle microphysiological systems (HF-MPS), which aim to better replicate the immune, vascular, neural, and dynamic regulatory features of native hair follicles. These systems are particularly important for studying immune-mediated hair disorders like alopecia areata, where immune privilege collapse and inflammatory infiltration are key issues. The review outlines the structural basis of HF engineering and defines immune competence as maintaining immune privilege, regulating hair follicle cycling and regeneration, and managing inflammatory injury. It also explores engineering strategies such as local immune microenvironment control and dynamic perfusion. The applications of HF-MPS in disease modeling, drug evaluation, and regenerative medicine are discussed, emphasizing that these systems are evolving platforms rather than complete replacements for existing models.
research Revisiting Rosacea Through the Skin–Gut–Brain Axis: A Neuroimmune Perspective
Rosacea may be linked to gut and brain issues, not just a skin problem.
research The Functions and Mechanisms of TGF‐β3 Signalling in Controlling the Fate Determinations of Various Types of Stem Cells
TGF-β3 controls stem cell growth and development, varying by cell type and conditions.
research A Comprehensive Survey on Vitiligo Detection Using Deep Learning
Better datasets and methods are needed for reliable vitiligo detection using deep learning.
research 176 Characterising Neurotransmitter Signalling in Human Skin and Hair Follicles
Skin and hair cells release serotonin and histamine naturally, which could help improve skin health.
research SYNERGIA AI I MEDYCYNY: SZANSE I WYZWANIA
AI is transforming healthcare by improving diagnostics and therapy, despite challenges with data and trust.
research Biomedical engineering approaches for the delivery of JAGGED1 as a potential tissue regenerative therapy
JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.
research The Dark Side of the Language: Pre-trained Transformers in the DarkNet
Pre-trained Transformers need extreme retraining to perform well on DarkNet data.
research 1301 STIM1, but not STIM2, is the calcium sensor critical for sweat secretion
STIM1 is essential for sweat secretion.
research A matter of life and death: self‐renewal in stem cells
Stem cell self-renewal is complex and needs more research for full understanding.
research Safety of testosterone treatment in postmenopausal women
Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.
research Attempted construction of minoxidil: carboxylic acid cocrystals; 7 salts and 1 cocrystal resulted
Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
research The Role of Oral Contraceptives in the Treatment of Hyperandrogenic Disorders
Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.
research Solubilizing steroidal drugs by β-cyclodextrin derivatives
Using β-cyclodextrin derivatives improves the solubility and bioavailability of steroidal drugs.
research Neuropeptídeos na pele
Neuropeptides affect skin inflammation, repair, and hair growth, with potential for therapy.
research Dynamic Behavior and Spontaneous Differentiation of Mouse Embryoid Bodies on Hydrogel Substrates of Different Surface Charge and Chemical Structures
Hydrogel surface properties affect mouse embryoid body differentiation.
research Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2
Keratin from hair binds well to gold and BMP-2, useful for bone repair.
research Different localizations of drugs simultaneously administered in a strand of hair by micro‐segmental analysis
Drugs localize differently in hair strands based on their properties.
research Histochemical evidence of mucosubstances in the metaplastic epidermis and hair follicles produced in vitro in the presence of excess vitamin A
Excess vitamin A changes skin and hair follicle development and affects polysaccharide distribution.
research Polycystic ovary syndrome is associated with weight‐loss attempts and perception of overweight independent of BMI: a population‐based cohort study
Women with PCOS often try to lose weight and see themselves as overweight, regardless of their actual BMI.
research Vitamins A, B, C, and D: A Short Review for the Dermatologist.
Vitamins A, B, C, and D are important for skin health and are being explored for new uses, but more research is needed to confirm their effectiveness.
research Identification of novel mutation in theHRgene responsible for atrichia with papular lesions in a Pakistani family
Researchers found a new mutation in the HR gene causing hair loss and skin bumps in a Pakistani family.
research The lipide composition of epidermis and dermis of mice undergoing carcinogenesis by methylcholanthrene.
Cholesterol and phospholipids increase in mouse skin during cancer development, with differences between male and female skin.
research Silver Nanoparticles Derived from Artocarpus heterophyllus for Antimicrobial Nano-gels:A Green Synthesis Approach
Jackfruit leaf-derived silver nanoparticles in gel form effectively fight infections, especially against E. coli.
research Clinical benefits and adverse effects of genetically-elevated free testosterone levels: a Mendelian randomization analysis
Higher free testosterone levels can increase bone density and decrease body fat but may raise the risk of prostate cancer, hair loss, and benign prostate enlargement.
research Bipolar Patients and Bullous Pemphigoid after Risperidone Long-Acting Injectable: A Case Report and a Review of the Literature
Long-term use of Risperidone may be linked to a serious skin condition in bipolar patients, affecting their overall well-being.