![Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase](/images/research/d91300a7-4d66-4d2c-90ac-293b0dbc5ff5/small/21048.jpg)
research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase
Compound 15a was effective in inhibiting 5α-reductase.
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630-660 / 1000+ results research Carbon quantum dots applied to the chemical sensing of cobalt ions and methylcobalamin
Carbon Quantum Dots can effectively detect cobalt ions and methylcobalamin in water.
research Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework
A new method effectively predicts estrogen-related health effects for early screening.
research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.
GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.
research Dual Wavelength LEDs Induce Reactive Oxygen Species and Nitric Oxide That Inhibit the Production of Dihydrotestosterone by 5‐α Reductase
Dual wavelength LEDs may help reduce hair loss by lowering DHT levels.
research Activity Test of Combination of Binahong Leaf Extract (Anredera Cordifolia) and Lemongrass Extract (Cymbopogon citratus) as Antifungal Againt Pityrosporum ovale
The combination of binahong leaf and lemongrass extracts effectively fights dandruff-causing fungus.
research The Effect of a Combination of an Arginine Silicate Complex and Magnesium Biotinate on Hair and Nail Growth in Rats (P06-026-19)
A combination of arginine silicate complex and magnesium biotinate improves hair and nail growth in rats.
research Identification and in-silico analysis of phytochemicals from Phyla nodiflora (L.): Potential bioactive compounds for therapeutic applications
Phyla nodiflora contains compounds that may help treat diabetes, alopecia, cancer, and anti-diuresis.
research Effect of a non-ionic surfactant on skin-retention of cationic minoxidil microparticles suspended in an anionic surfactant solution
Adding Brij 78 to minoxidil microparticles in a certain solution helps them stick to the skin better and prevents clumping.
research The Development of Squid Ink Melanin Nanoparticles as a Multifunctional Colorant Anchored on Hair Fibers: Preparation, Physicochemical Characterization and Dyeing Performance
Squid ink melanin nanoparticles create a safe, long-lasting black hair dye that protects hair and offers UV protection.
research Determination of Minoxidil by Bleaching the Permanganate Carrier Solution in a Flow-Based Spectrophotometric System
The method quickly and accurately measures minoxidil in drugs, comparable to standard techniques.
research Spectrophotometric method for the estimation of finasteride in tablets
A new method accurately measures finasteride in tablets using color change and light absorption.
research Antimicrobial and Antibiofilm Activities of Abietic Acid against Skin-Associated Opportunistic Microorganisms
Abietic acid from pine rosin can effectively fight and reduce harmful skin microbes.
research Niosomes as Efficient Nanocarriers for Targeted Drug Delivery
Niosomes are effective carriers for targeted drug delivery, improving drug stability and efficiency.
research Inhibition of 5α-reductase in the rat prostate by Cimicifuga racemosa
Cimicifuga racemosa extract may help prevent and treat prostate issues by inhibiting 5α-reductase.
research Oral intake of anti-hangover substance increases aldehyde dehydrogenase activity: New preventive and therapeutic potentials for oxidative neuronal injury?
The anti-hangover product may boost enzyme activity to help prevent brain damage.
research Use of Silver in the Prevention and Treatment of Infections: Silver Review
Silver can help prevent and treat infections but its effectiveness varies and should be weighed against costs and side effects.
research Regulatory Roles of Cytokinins and Cytokinin Signaling in Response to Potassium Deficiency in Arabidopsis
Reduced cytokinin levels help plants adapt to low potassium by increasing root hair growth and potassium uptake.
research Pustular allergic contact dermatitis caused by fragrances
Avoiding certain fragrances improved the man's skin condition.
research Diclofenac/imiquimod
Some elderly men had healing problems after using imiquimod and diclofenac for skin conditions on their scalps.
research 0955 Selective BET inhibition as potential hidradenitis suppurativa treatment
research Antioxidant Capacity of Essential Oils Obtained from Myrtus communis L. and Citrus sinensis (L.) Osbeck Plants Widely Consumed in Adana Region
Myrtle essential oil has a higher antioxidant capacity than orange essential oil.
research LB1157 Befriending the bugs: An updated meta-analysis on the efficacy of probiotic intervention in reducing scorad scores in atopic dermatitis
Probiotics significantly reduce the severity of atopic dermatitis.
research Biotransformation of Finasteride (MK-0906) by Selenastrum capricornutum (Green Algae)
Green algae can break down finasteride, reducing environmental harm.
research A new label-free screen for steroid 5α-reductase inhibitors using LC-MS
Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.
research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility1
PNU157706 reduced rat sperm movement and fertility without affecting offspring health.
research The reduction of selenium(IV) by boreal Pseudomonas sp. strain T5-6-I – Effects on selenium(IV) uptake in Brassica oleracea
Pseudomonas sp. T5-6-I bacteria increase selenium uptake in Brassica oleracea plants by 130%.
research 17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level
Some synthesized compounds were more effective than Finasteride in reducing prostate cancer cell growth and androgen levels.
research Protective role of hesperidin in finasteride-induced testicular toxicity in adult male Wistar rats: Insights into oxidative stress, apoptosis, and ultrastructure of seminiferous tubules
Hesperidin helps protect against testicular damage caused by finasteride.
research Preparation of a highly specific single chain variable fragment antibody targeting miroestrol and its application in quality control of Pueraria candollei by enzyme‐linked immunosorbent assay
The new ELISA method is reliable and eco-friendly for checking the quality of Pueraria candollei.