Search

for
Search:

GlossaryNLRP3

protein involved in immune response and inflammation regulation

NLRP3 is a protein that plays a crucial role in the body's immune response. It is part of a larger complex called the inflammasome, which helps detect harmful substances and triggers inflammation to fight off infections. In some cases, overactivation of NLRP3 can lead to chronic inflammatory diseases.

Related Terms

Sort by

Research

30 / 523 results

research Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing

13 citations , February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata

5 citations , September 2024 in “Biomolecules and Biomedicine”

Total glucosides of paeony may help treat alopecia areata by reducing inflammation and hair loss.

Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

research Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

5 citations , November 2022 in “Molecular Neurobiology”

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata

October 2024 in “Benha Medical Journal”

Patients with Alopecia Areata have higher levels of certain inflammatory markers.

research 1,25-(OH)2D3 promotes hair growth by inhibiting NLRP3/IL-1β and HIF-1α/IL-1β signaling pathways

June 2024 in “The Journal of Nutritional Biochemistry”

1,25-(OH)2D3 helps hair grow by blocking certain harmful signals.

research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis

April 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

research Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair

January 2026 in “Burns & Trauma”

NLRP3 helps control inflammation and repair in wound healing, making it a potential target for treatment.

Protective Role of Agomelatine via Modulation of TLR4/NF-κB: NLRP3/IL-1β Signaling Pathways in Testosterone-Induced Benign Prostatic Hyperplasia in Rats

research Protective role of agomelatine via modulation of TLR4/NF-κB: NLRP3/IL-1β signaling pathways in testosterone-induced benign prostatic hyperplasia in rats

December 2025 in “Naunyn-Schmiedeberg s Archives of Pharmacology”

Agomelatine may help reduce benign prostatic hyperplasia by blocking certain inflammatory pathways.

research Mechanism of action of NLRP3 protein macromolecule based on electrochemical sensors in the treatment of alopecia areata in mice: The role of Ritlecitinib in AA mice through NLRP3

March 2026 in “Microchemical Journal”

Advancements in Research on the Immune-Inflammatory Mechanisms Mediated by NLRP3 Inflammasome in Ischemic Stroke and the Regulatory Role of Natural Plant Products

research Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products

18 citations , March 2024 in “Frontiers in Pharmacology”

Natural plant products like Proanthocyanidins and curcumin may help treat ischemic stroke by reducing inflammation.

research NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

50 citations , August 2019 in “Cell Communication and Signaling”

NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.

research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease

41 citations , May 2020 in “Frontiers in immunology”

Hidradenitis suppurativa might be a type of autoinflammatory skin disease.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

22 citations , March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research ADSCs inhibit photoaging‐ and photocarcinogenesis‐related inflammatory responses and extracellular matrix degradation

19 citations , August 2019 in “Journal of Cellular Biochemistry”

ADSCs help protect skin from UV damage and aging.

Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition

research Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

4 citations , September 2023 in “Stem cell research & therapy”

Special particles from umbilical cord stem cells help heal skin wounds in diabetic mice by preventing certain immune cell death.

research Aberrant inflammasome activation as a driving force of human autoimmune skin disease

3 citations , May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

Smart Fluids as Autophagy-Activating Photoprotectors: In Vitro Analysis of Dead Sea Water and Magnetized Saline Water Against Ultraviolet B (UVB)-Induced Photodamage in Human Keratinocytes

research Smart Fluids As Autophagy-Activating Photoprotectors: In Vitro Analysis of Dead Sea Water and Magnetized Saline Water Against Ultraviolet B (UVB)-Induced Photodamage in Human Keratinocytes

1 citations , April 2025 in “Cureus”

Dead Sea water and magnetized saline water can protect skin from UVB damage by activating autophagy.

research Disrupted citric acid metabolism inhibits hair growth

1 citations , July 2022 in “Journal of dermatology”

Disrupted citric acid metabolism stops hair growth.

research 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage

1 citations , April 2016 in “Journal of Investigative Dermatology”

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

research Inflammasome Proteins as Biomarkers of Injury and Disease

January 2014 in “Springer eBooks”

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.

research Fermented Yeast Complex Extract Promotes Hair Regrowth by Decreasing Oxidative Stress

December 2025 in “Antioxidants”

Fermented Yeast Complex Extract helps regrow hair by reducing oxidative stress and inflammation.

The Possible Role of PTEN-Induced Kinase 1-Mediated Mitophagy in Regulating Inflammasome Activation in the Pathogenesis of Alopecia Areata

research 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating mitophagy may help manage a key immune response involved in the hair loss condition alopecia areata.

research Acne-Associated Syndromes

January 2019 in “Springer eBooks”

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

research The role of skin macrophages under conditions of stress and injury: ultraviolet irradiation and wound healing

December 2018

Inhibiting IL-17 and IL-23 improves wound healing in obese, diabetic mice by promoting healing macrophages.

research 646 SOX4 is essential for melanoma tumorigenesis

April 2016 in “Journal of Investigative Dermatology”

SOX4 is crucial for the development of melanoma.