research Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress
Melatonin may protect ear cells from damage caused by nicotine.
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research DTC pharmaceutical advertising: the debate’s not over
The debate on direct-to-consumer pharmaceutical ads continues, with consumers finding them educational and doctors concerned about their impact on patient relationships and medication understanding.
research Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A potential contributor to Post-Finasteride Syndrome
Finasteride may cause changes in dopamine-related genes, possibly leading to post-finasteride syndrome.
research Early removal of the Norplant System.
Many women removed the Norplant implant early due to side effects like headaches and irregular bleeding, indicating a need for better patient counseling.
research Patient-Reported Outcomes From Phase III Neoadjuvant Systemic Trial Comparing Neoadjuvant Chemotherapy With Neoadjuvant Endocrine Therapy in Pre-Menopausal Patients With Estrogen Receptor-Positive and HER2-Negative, Lymph Node-Positive Breast Cancer
Neoadjuvant endocrine therapy led to a better future outlook than chemotherapy, with no major quality of life differences.
research Circadian rhythm sleep-wake disorders (CRSWDs): Linking circadian misalignment to adverse health outcomes.
Disruptions in sleep-wake cycles can cause health problems like mental, metabolic, and heart diseases, and cancer.
research Atherogenesis: Estrogen Induction of Polysialylated nCAM (PSA-nCAM) Blocks Monocyte Capture by Vascular Endothelial Cells
Estrogen helps prevent artery plaque by stopping monocyte capture in blood vessels.
research Trazodone by epigenetic mechanism can reverse the post finasteride syndrome
Trazodone might help reverse post finasteride syndrome.
research Perceived Functional Impact of Abnormal Facial Appearance; Marlene Rankin, Ph.D., and Gregory L. Borah, M.D.
People with facial disfigurements are judged more negatively, highlighting the social benefits of corrective surgery.
research Choice of recall period for patient-reported outcome (PRO) measures: criteria for consideration
Choosing the right recall period for patient feedback is important for accurate data and depends on the disease, symptom changes, and patient impact.
research Nail Hyperpigmentation Following Valproic Acid Use: A Rare Case Report
Valproic acid can rarely cause reversible nail discoloration.
research Regarding Conscious and Deep Sedation
Propofol can easily cause deep sedation, so caution is needed when using it for procedures.
research When bugs and drugs conspire: driving acneiform skin toxicity
Certain cancer drugs interact with skin bacteria to cause acne-like rashes.
research Nanocarriers for melatonin delivery
Nanocarriers make melatonin more effective and reduce side effects.
research Effects of the COVID-19 Pandemic On Patient Social Media Use and Acceptance of Cosmetic Procedures.
More social media use during COVID-19 increased interest in cosmetic procedures.
research Dacomitinib-Induced Paronychia Associated With PRIDE Syndrome in a Patient With Non-Small Cell Lung Cancer
Dacomitinib can cause nail and skin issues, but these can be managed without stopping the drug.
research Chronic Exposure of 5‐Alpha Reductase Inhibitor in Young Male Rats Induces Not Only Metabolic Disturbance, But Also Depressive‐Like Behaviors as Similar with Obese Condition
Long-term use of a drug for hair loss and prostate issues can cause metabolic problems and depression-like behavior in young male rats.
research Cutaneous applied nano-ZnO reduce the ability of hair follicle stem cells to differentiate
Nano-Zinc oxide on skin reduces hair follicle stem cell differentiation.
research The Charnoly body as a universal biomarker of cell injury
Charnoly bodies could be a marker for cell damage, and certain nutrients and proteins might prevent them, potentially helping with brain diseases and cancer.
research Testosterone Conversion Blockade Increases Breathing Stability in Healthy Men during NREM Sleep
Blocking testosterone action may improve breathing during NREM sleep in healthy men.
research Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes
Neurosteroids may help treat disorders with too much dopamine activity.
research Unexpected refractory hypotension following intradermal minoxidil injection
research Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens
Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.
research How routine pharmacovigilance failed to identify finasteride’s persistent sexual side effects
Finasteride, a hair loss drug, has unaddressed sexual side effects due to the manufacturer's inadequate safety measures and lack of additional studies.
research Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat
Finasteride reduces pain in male rats and works better with testosterone.
research Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications
Neurotoxins can affect neurotransmitter release and have potential in treating muscle, pain, and cancer conditions, but more research is needed on how they work.
research Hair growth-modulation by adrenergic drugs
Certain drugs can cause early hair growth in mice by affecting the nerves.
research Social isolation alters GABAA receptors plasticity and function: effect of voluntary consumption of ethanol
Social isolation changes brain receptors and makes ethanol more impactful.
research Finasteride-induced depression: new insights into possible pathomechanisms
Finasteride may increase depression by reducing brain cell growth.
research The neurosteroid metabolite of progesterone, 3α‐OH‐dihydroprogesterone (3α‐OH‐DHP), is required for attenuated baroreflex mediated sympathoexcitation in pregnancy
3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.