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GlossaryNon-canonical Wnt Pathway

regulates cell movement and organization without using β-catenin

The Non-canonical Wnt Pathway is a signaling pathway that operates independently of the β-catenin protein, which is central to the canonical Wnt pathway. This pathway is involved in regulating various cellular processes such as cell movement and organization, and it includes sub-pathways like the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway. These pathways play crucial roles in embryonic development, tissue regeneration, and diseases, including certain types of alopecia.

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4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research XEDAR activates the non-canonical NF-κB pathway

18 citations , August 2015 in “Biochemical and Biophysical Research Communications”

XEDAR triggers a specific signaling pathway in cells.

research 0748 Synergy of TP53 and non-canonical sonic hedgehog pathway in the development of complex basal cell carcinoma

July 2025 in “Journal of Investigative Dermatology”

Complex basal cell carcinomas need personalized treatment due to unique genetic mutations.

research Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway

11 citations , October 2017 in “Oncotarget”

Gsdma3 affects hair growth by controlling Wnt5a, which influences hair cell development.

Cthrc1 Deficiency Aggravates Wound Healing and Promotes Cardiac Rupture After Myocardial Infarction via Non-Canonical WNT5A Signaling Pathway

research Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway

9 citations , January 2023 in “International Journal of Biological Sciences”

CTHRC1 is essential for healing and preventing heart rupture after a heart attack.

research Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes

April 2010 in “Cancer Research”

Mcl-1 can activate Wnt signaling in skin cells, promoting growth and possibly cancer.

research Canonical and non-canonical Wnt signaling control the regeneration of amputated rodent vibrissae follicles

5 citations , January 2016 in “Journal of Molecular Histology”

Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.

research Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury.

September 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Special gut cells help stem cells move to and fix injured areas by activating a specific signaling pathway.

research Wnt signaling in skin organogenesis

72 citations , April 2008 in “Organogenesis”

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Wound Healing in Development: Mechanisms and Regulation

research Wound healing in development

29 citations , September 2012 in “Birth Defects Research”

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

research Targeting of Smoothened for therapeutic gain

105 citations , April 2014 in “Trends in Pharmacological Sciences”

Targeting the Smoothened receptor shows promise for treating certain cancers.

research Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration

10 citations , November 2020 in “American Journal Of Pathology”

Integrin β1 is crucial for liver structure and function, preventing fibrosis.

research Regulatory Processes of the Canonical Wnt/β-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair

11 citations , April 2022 in “International Journal of Molecular Sciences”

Understanding the Wnt/β-catenin pathway and photobiomodulation could improve diabetic wound healing.

research AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

60 citations , October 2020 in “Nature Communications”

AP-1 and TGFß work together to drive resistance in basal cell carcinoma, suggesting new treatment options.

research The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

16 citations , March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.

research 877 Small T antigen from a folliculotropic polyomavirus activates canonical Wnt/β-catenin signaling in vivo

April 2017 in “Journal of Investigative Dermatology”

A virus protein can activate a pathway that may lead to abnormal hair follicle development.

Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice

research Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

23 citations , January 2018 in “International Journal of Molecular Medicine”

Baicalin helps hair growth by activating specific cell signals and pathways.

research Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems

21 citations , January 2023 in “The International Journal of Developmental Biology”

The Wnt signaling pathway is crucial for regeneration and could help advance human medicine.

research EMT Factors and Metabolic Pathways in Cancer

346 citations , April 2020 in “Frontiers in Oncology”

EMT and metabolic pathways help cancer cells resist treatment and spread.

research Author response: Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

December 2019

Sphingosine 1-phosphate affects inflammation and gene expression in different aorta cells.

research Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts

24 citations , March 2021 in “Frontiers in Cell and Developmental Biology”

Wnt signaling is disrupted in asthma, affecting cell growth and inflammation.

research BMI1 is required for melanocyte stem cell maintenance and hair pigmentation

4 citations , May 2023 in “Pigment Cell & Melanoma Research”

BMI1 is essential for preventing hair greying and maintaining hair color.

research Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury

57 citations , December 2021 in “Nature Communications”

Non-canonical Wnt signaling helps intestinal stem cells move to injury sites for tissue repair.

research Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease

25 citations , June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.

An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

research An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia

12 citations , June 2017 in “Cell Cycle”

Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.

Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

research Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells

July 2023 in “Current Issues in Molecular Biology”

Escin may help treat hair loss by boosting a specific cell growth pathway.

research Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics

16 citations , February 2014 in “Journal of Investigative Dermatology”

Researchers developed a mouse model that tracks hair growth using bioluminescence, improving accuracy in studying hair cycles.

Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

research Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

14 citations , November 2007 in “Journal of Dermatological Science”

Vitamin C derivative may promote hair growth by activating specific genes.

research Adenovirus-Mediated Wnt5a Expression Inhibits the Telogen-To-Anagen Transition of Hair Follicles in Mice

19 citations , January 2013 in “International journal of medical sciences”

Increasing Wnt5a in mice skin delays hair growth but doesn't stop it.

research Mechanotransduction unifies healthy non-diabetic wound healing over time by promoting a Cd14+/C1qa+ fibroblast subpopulation

April 2026 in “Journal of Investigative Dermatology”

Mechanotransduction aids healthy wound healing by promoting specific fibroblasts.