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GlossaryNR1D2

gene encoding a nuclear receptor involved in circadian rhythm regulation

NR1D2, also known as Rev-erbβ, is a gene that encodes a nuclear receptor involved in regulating circadian rhythms and metabolism. It plays a crucial role in the body's internal clock and can influence various biological processes, including sleep-wake cycles and energy balance.

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research Molecular insights into chronotype and time-of-day effects on decision-making

36 citations , July 2016 in “Scientific reports”

People's decision-making can be influenced by their internal biological clocks, as shown by gene expression, not just self-reported preferences for morning or evening.

research Diurnal Preference Predicts Phase Differences in Expression of Human Peripheral Circadian Clock Genes

28 citations , June 2015 in “Journal of circadian rhythms”

An individual's morning or evening preference can predict changes in their body clock gene expression.

research Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells

15 citations , October 2012 in “Journal of circadian rhythms”

RNA from horse hair follicles can track circadian rhythms non-invasively.

Estimation Methods for Human Circadian Phase Using Peripheral Tissues

research Estimation methods for human circadian phase by use of peripheral tissues

14 citations , June 2016 in “Hypertension research”

New method uses hair follicle cells to estimate human body clock phase, potentially improving sleep disorder diagnosis.

research The effect of night shift work on the expression of clock genes in beard hair follicle cells

12 citations , January 2019 in “Sleep medicine”

Night shift work disrupts the body's natural clock genes.

research Effects of bright light exposure during daytime on peripheral clock gene expression in humans

5 citations , December 2016 in “International journal of biometeorology”

Bright light during the day doesn't change most human clock genes but may slightly increase Rev-erb-ß.

research A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

92 citations , September 2013 in “Journal of Investigative Dermatology”

BMAL1 and Period1 genes can influence human hair growth.

research 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration

April 2019 in “Journal of Investigative Dermatology”

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

research Noninvasive method for assessing the human circadian clock using hair follicle cells

166 citations , August 2010 in “Proceedings of the National Academy of Sciences of the United States of America”

Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.

research Stem cells and the circadian clock

75 citations , September 2017 in “Developmental biology”

The circadian clock influences the behavior and regeneration of stem cells in the body.

research Four days of simulated shift work reduces insulin sensitivity in humans

50 citations , January 2018 in “Acta physiologica”

Working night shifts for four days can lower the body's ability to use insulin, which may increase the risk of type 2 diabetes.

research Possible contribution of chronobiology to cardiovascular health

29 citations , January 2014 in “Frontiers in physiology”

Understanding and tracking our body's natural daily rhythms could help improve heart health.

Multimodal Profiling Reveals Site-Specific Adaptation and Tissue Residency Hallmarks of Gamma Delta T Cells Across Organs in Mice

research Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice

23 citations , January 2024 in “Nature Immunology”

γδ T cells adapt uniquely to different tissues in mice.

research An out-of-lab trial: a case example for the effect of intensive exercise on rhythms of human clock gene expression

21 citations , September 2013 in “Journal of circadian rhythms”

Intense exercise at night can delay the body's internal clock gene expression by 2 to 4 hours.

Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% for Sustainable Hair Regrowth

research Low‐Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% to Bring a Sustainable Hair Regrowth Activity

4 citations , May 2021 in “Lasers in Surgery and Medicine”

Light therapy reduces scalp inflammation, boosts hair regrowth with Minoxidil 2%.

research Author response: The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome

April 2016

Defective protein folding due to a mutation is key in ANE syndrome.

research A new mutation Rim3 resembling Re den is mapped close to retinoic acid receptor alpha (Rara) gene on mouse Chromosome 11

76 citations , January 1998 in “Mammalian Genome”

research Novel RNF113A Variant Underlying X‐Linked Trichothiodystrophy With Presumed Mosaicism in an Unaffected Mother

January 2026 in “American Journal of Medical Genetics Part A”

A new genetic variant causes trichothiodystrophy in two brothers, but their mother may carry it without showing symptoms.

research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

139 citations , December 2020 in “Cell Stem Cell”

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

123 citations , December 2015 in “Journal of Neuroendocrinology”

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

research Sex differences in COVID-19: the role of androgens in disease severity and progression

121 citations , November 2020 in “Endocrine”

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

research Baiting Proteins with C₆₀

106 citations , April 2010 in “ACS Nano”

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Cloning of a Functional Vitamin D Receptor from the Lamprey, an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

104 citations , May 2003 in “Endocrinology”

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

research Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

91 citations , August 2014 in “Development”

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

research Flares of systemic lupus erythematosus during pregnancy and the puerperium: prevention, diagnosis and management

87 citations , July 2012 in “Expert Review of Clinical Immunology”

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

research Circadian clocks: from stem cells to tissue homeostasis and regeneration

84 citations , December 2017 in “EMBO Reports”

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

research Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD

59 citations , November 2018 in “Psychoneuroendocrinology”

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

research Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture

42 citations , March 2018 in “PLOS Biology”

Autophagy is important for human hair growth and health.

research How drug repurposing can advance drug discovery: challenges and opportunities

33 citations , August 2024 in “Frontiers in Drug Discovery”

Drug repurposing is a faster, cheaper way to develop new treatments using existing drugs.

research Thyroxine Differentially Modulates the Peripheral Clock: Lessons from the Human Hair Follicle

30 citations , March 2015 in “PLoS ONE”

Thyroxine can adjust the body's peripheral clock, potentially helping treat clock-related diseases.