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Did you mean Estrogen Receptor Alpha?

GlossaryEstrogen Receptor Alpha

protein inside cells that binds to estrogen hormone

Estrogen Receptor Alpha (ERα) is a protein found inside cells that binds to the hormone estrogen. This receptor is crucial for regulating various biological processes, including reproductive functions and the development of certain tissues. In the context of hair and alopecia, ERα can influence hair growth and loss, as estrogen plays a role in the hair growth cycle.

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research The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta?

65 citations , May 2006 in “Journal of Investigative Dermatology”

Dexamethasone may influence hair growth by altering estrogen receptor activity in hair cells.

Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

research Combined oral contraceptives promote androgen receptor and oestrogen receptor alpha upregulation in the female prostate (Skene’s paraurethral glands) of adult gerbils (Meriones unguiculatus)

3 citations , January 2018 in “Reproduction, Fertility and Development”

Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.

research Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

October 2025 in “Frontiers in Toxicology”

A new method effectively predicts estrogen-related health effects for early screening.

research Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells

March 2026 in “Scientific Reports”

Ferulic acid may help hair grow by activating certain receptors in cells.

Early Androgen Activity After Birth Determines the Hypothalamic Expression of Androgen and Estrogen Receptors in Adulthood in Female but Not in Male Rats

research Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

July 2025 in “Reproductive Biology and Endocrinology”

Early androgen exposure affects hormone receptor expression in adult female rats' brains, but not in males.

Complex Extract of Polygonatum Sibiricum and Nelumbinis Semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

research Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

May 2023 in “Nutrients”

A mix of Polygonatum sibiricum and Nelumbinis semen may ease menopause symptoms with fewer side effects.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling

92 citations , February 2005 in “Endocrinology”

Estrogen receptors affect hair growth, with ER beta slowing down the hair cycle changes caused by ER alpha.

Pharmacological Activation of Estrogen Receptors-α and -β Differentially Modulates Keratinocyte Differentiation with Functional Impact on Wound Healing

research Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing

23 citations , September 2015 in “International Journal of Molecular Medicine”

Activating ER-β, not ER-α, improves skin cell growth and wound healing.

research Role of estrogen receptor signaling in the control of the hair follicle cycle

January 2004

Estrogen and its receptors play a key role in hair growth, with differences between males and females.

research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

Estrogen affects hair growth and skin cell multiplication.

research 17β-Estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-α pathway

71 citations , February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

Estradiol stops hair growth in mice, but an antagonist can reverse this effect.

research 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α

38 citations , May 2010 in “American Journal Of Pathology”

17β-Estradiol slows wound healing in male mice through estrogen receptor-α.

Sex Steroid Hormone Receptors in Human Skin Appendages and Their Neoplasms

research Sex Steroid Hormone Receptors in Human Skin Appendage and its Neoplasms

59 citations , January 2005 in “Endocrine Journal”

Sex steroids influence skin appendage function and neoplasm development, with changes in AR and ERalpha in certain gland neoplasms.

research Estrogen and androgen signaling in the pathogenesis of BPH

149 citations , January 2011 in “Nature reviews. Urology”

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

research Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study

29 citations , October 2020 in “Environmental health perspectives”

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

research Localization of sex steroid receptors in human skin.

147 citations , April 2004 in “PubMed”

Sex steroid receptors are found in specific skin cells, affecting skin and hair functions.

Estrogen-Dependent Development of Sex Differences in Somatostatin Neurons of the Hypothalamic Periventricular Nucleus

research Estrogen-Dependent Ontogeny of Sex Differences in Somatostatin Neurons of the Hypothalamic Periventricular Nucleus*

19 citations , March 1998 in “Endocrinology”

Male rats have more somatostatin neurons than females due to testosterone converting to estrogen during early development.

research Ovarian sex steroid receptors and sex hormones in androgenized rats

13 citations , August 2016 in “Reproduction”

High doses of nandrolone decanoate disrupt ovarian hormones and receptors in rats, with recovery only at lower doses and longer recovery times.

research The premature catagen induced by estrogen was accompanied with advance apoptosis of precortex cells.

December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)”

Estrogen speeds up hair follicle cell death, causing early hair growth cycle changes, but only if a specific receptor is present.

research 202 Activation of breast cancer cell proliferation by ROR-alpha through aromatase promoter

March 2010 in “Ejc Supplements”

ROR-alpha may increase the growth of certain breast cancer cells by boosting aromatase, which could affect breast cancer prognosis.

research Localised breast cancers may have systemic influences on skin and hair

2 citations , June 2006 in “Journal of Clinical Pathology”

Localized breast cancer can affect skin and hair.

research Melatonin and the hair follicle

109 citations , October 2007 in “Journal of pineal research”

Melatonin helps regulate hair growth and protects the hair follicle from stress.

research Endocrinology of the Aging Prostate: Current Concepts

21 citations , February 2021 in “Frontiers in Endocrinology”

Hormones affect prostate health and disease, with certain hormone imbalances linked to prostate cancer and benign prostatic hyperplasia.

research A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice

3 citations , July 2013 in “Bioscience, Biotechnology, and Biochemistry”

Chinese black tea extract helped mice grow hair, especially when combined with capsaicin.

research The postnatal offspring of finasteride-treated male rats show altered ERα and PCNA expression in the liver

July 2025 in “Reproductive Biology”

Finasteride use in male rats may harm their male offspring's liver function.

research Dihydrotestosterone Induces Arterial Stiffening in Female Mice

February 2023 in “Research Square (Research Square)”

Dihydrotestosterone increases arterial stiffness in female mice without changing blood pressure or aortic wall thickness.

research Hormonal therapy in female pattern hair loss

21 citations , February 2017 in “International Journal of Women's Dermatology”

Hormonal therapies help treat female hair loss, but results are slow and vary.

research Endocrine control of benign prostatic hyperplasia

97 citations , April 2016 in “Andrology”

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

research 5α‐Reductase Isozymes and Androgen Actions in the Prostate

93 citations , February 2009 in “Annals of the New York Academy of Sciences”

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.