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Did you mean Oligomeric Proanthocyanidins?

GlossaryOligomeric Proanthocyanidins

Oligomeric proanthocyanidins (OPCs) are a class of flavonoids found in various plants, particularly in grape seeds, pine bark, and certain fruits. They are known for their antioxidant properties, which can help protect hair follicles from oxidative stress, a factor that contributes to hair loss. OPCs may also promote blood circulation and improve nutrient delivery to hair follicles, potentially supporting hair growth. Their relevance in hair biology lies in their ability to combat inflammation and promote overall scalp health, making them a subject of interest in hair loss treatments.

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Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption

research Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption

282 citations , April 2007 in “Journal of Agricultural and Food Chemistry”

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

A Semisynthetic Approach for the Simultaneous Reaction of Grape Seed Polymeric Procyanidins with Catechin and Epicatechin to Obtain Oligomeric Procyanidins in Large Scale

research A semisynthetic approach for the simultaneous reaction of grape seed polymeric procyanidins with catechin and epicatechin to obtain oligomeric procyanidins in large scale

9 citations , April 2019 in “Food Chemistry”

Created large amounts of grape seed compounds using a new method.

research Biological actions of oligomeric procyanidins: Proliferation of epithelial cells and hair follicle growth

8 citations , January 2001 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Oligomeric procyanidins may help hair grow by affecting cell growth and the hair growth cycle.

Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent

research Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair‐growing agent

28 citations , December 2005 in “Journal of cosmetic dermatology”

Apple procyanidin applied to the scalp may help grow hair without side effects.

Procyanidin Oligomers Counteract TGF-β1- and TGF-β2-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms

research Procyanidin Oligomers Counteract TGF-β₁- and TGF-β₂-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms

14 citations , January 2006 in “Skin pharmacology and physiology”

Procyanidin compounds from apples and barley promote hair growth and prevent hair cell death.

Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo

research Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo11The authors disclosed conflict of interest.

79 citations , March 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

Procyanidin compounds from grape seeds were found to significantly increase mouse hair growth.

research Effect of procyandin oligomers on oxidative hair damage

10 citations , January 2011 in “Skin research and technology”

Procyanidin oligomers can protect hair from oxidative damage and could be good for hair care products.

research Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

13 citations , December 2019 in “Nutrients”

An apple-based supplement was found to stimulate hair protein production, which may help with hair growth.

research Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent

32 citations , December 2000 in “Phytomedicine”

Apple-derived procyanidin B-2 can safely promote hair growth in men.

research Toxicological Studies on Procyanidin B-2 for Extern?al Application as a Hair Growing Agent

30 citations , May 1999 in “Food and chemical toxicology”

Procyanidin B-2 is safe to use on skin as a hair growth product.

research Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study

37 citations , January 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

Apple extract called procyanidin B-2 was found to greatly increase hair growth.

research Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2

22 citations , June 2018 in “Journal of Neuroinflammation”

Procyanidins from grape seeds reduce nerve pain by blocking specific proteins and inflammation.

research Procyanidin B-2 and the hair-growing activity of proanthocyanidins

1 citations , January 2001 in “Cosmetics and toiletries”

Procyanidin B-2 from apple juice significantly increases hair growth and may be more effective than minoxidil without side effects.

African Baobab (Adansonia Digitata) Fruit as a Promising Source of Procyanidins

research African baobab (Adansonia digitata) fruit as promising source of procyanidins

5 citations , February 2020 in “European Food Research and Technology”

African baobab fruit is a good source of antioxidants and micronutrients, but too much can cause laxative effects.

research A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention

13 citations , May 2019 in “Cancer Prevention Research”

Grape seed extract may safely and effectively help prevent lung cancer.

research Polyphenols from the Heartwood ofCercidiphyllum japonicumand their Effects on Proliferation of Mouse Hair Epithelial Cells

26 citations , November 2002 in “Planta medica”

Extracts from Cercidiphyllum japonicum wood can stimulate mouse hair cell growth like common hair growth treatments.

research Inhibitory Effects of Apple Polyphenols on Differentiation of 3T3-L1 Cells into Adipocytes.

18 citations , January 2000 in “Food Science and Technology Research”

Apple polyphenols, especially from unripe apples, can help prevent cells from turning into fat cells.

Evaluation of the Efficacy and Safety of Topical Procyanidin B2 and Placebo in the Treatment of Androgenetic Alopecia in Men: A Randomized, Double-Blind, Placebo-Controlled Study

research Evaluation of the efficacy and safety of topical procyanidin b2 and placebo in the treatment of androgenetic alopecia in men; A randomized, double-blind, placebo-controlled study

January 2022 in “Turk Dermatoloji Dergisi”

Topical procyanidin B2 significantly increases hair count and is a safe treatment for male pattern baldness.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations , August 2018 in “Skin appendage disorders”

Some alternative treatments for hair loss might work, but more research is needed.

research Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

24 citations , January 2020 in “International Journal of Molecular Sciences”

Some plants with flavonoids may help treat hair loss and promote hair growth.

research Hair Loss

January 2015 in “Springer eBooks”

Some alternative treatments may help with hair loss, but more evidence is needed to confirm their effectiveness.

research Can plant‐derived phytochemicals provide symptom relief for hair loss? A critical review

10 citations , June 2019 in “International Journal of Cosmetic Science”

Some plant-based chemicals may help with hair growth, but more research is needed to confirm their effectiveness.

research The Role of Botanical Products in the Treatment of Alopecia

January 2015 in “Hair therapy & transplantation”

Some botanical products may help increase hair growth in people with alopecia, but more research is needed.

research Malus pumila Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss

May 2024 in “FEBS open bio”

Annurca apple extract may help treat hair loss and protect against oxidative stress.

The Potential Use of Phenolic Compounds in the Treatment of Hair Loss: A Literature Review

research Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial

27 citations , September 2017 in “Journal of Medicinal Food”

Annurca apple supplement safely increases hair growth and keratin in humans.

research KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models

15 citations , April 2001 in “Journal of Dermatological Science”

KF19418 promotes hair growth similarly to minoxidil but is not better in live mice.

The New Paradigm for Androgenetic Alopecia and Plant-Based Folk Remedies: 5α-Reductase Inhibition, Reversal of Secondary Microinflammation, and Improving Insulin Resistance

research The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance

16 citations , September 2018 in “Journal of Ethnopharmacology”

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.