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Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Neurosteroids may help treat disorders with too much dopamine activity.

Targeting neurosteroids may help prevent drug relapse.

Medroxyprogesterone acetate is as effective as oral contraceptives for resuming ovulation in women with PCOS.

GLP-1 receptor agonists can cause skin reactions, facial fat loss, and hair loss, but may help with wound healing and skin conditions.

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Using existing drugs for new purposes could be a cost-effective way to treat chest pain and non-clogged heart arteries, with some drugs for lung blood pressure showing promise but needing more testing.

D'orenone stops root hair growth by disrupting auxin transport, but adding auxin can reverse this.

Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.

Paroxetine relieves pain by increasing allopregnanolone levels.

The model successfully predicted new uses for existing drugs, like using certain hormonal and heart medications for respiratory and Parkinson's diseases, and a cancer drug for diabetes.

New itaconate prodrugs improve its absorption and effectiveness for treating inflammation.

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

Metyrapone effectively stabilizes severe Cushing's disease symptoms before surgery.

RY-023, a specific drug, can improve early stage memory learning without affecting general activity in rats, but it's less effective for later learning stages and doesn't impact memory recall.

Ocoxin improves quality of life for advanced ovarian cancer patients on chemotherapy.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

SARMs show promise but need more evidence to prove they're better than traditional androgens.

Environmental factors can greatly reduce drug levels in hair.

Researchers made two new compounds that could be used for medicine.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Choose treatments for sex offenders based on individual needs, using hormonal and nonhormonal options to reduce sexual drive.

Pranlukast and mirabegron may work as new diabetes drugs.

Blocking GABA(A) receptors increases neuron sensitivity, showing GABA and glycine have different roles in pain.

Some drugs have gained approval for new uses, while others like tricyclic antidepressants and aspirin show promise but aren't yet approved for these uses.

Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.