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GlossaryOxidative Stress

imbalance between free radicals and antioxidants causing cellular damage

Oxidative stress refers to an imbalance between free radicals (unstable molecules that can damage cells) and antioxidants (molecules that neutralize free radicals) in the body. This imbalance can lead to cellular damage, also known as oxidative damage or oxidative injury, and is implicated in various conditions, including aging, cancer, and hair loss disorders like alopecia.

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Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling

22 citations , July 2015 in “PloS one”

Foxp1 helps control hair stem cell growth and response to stress during hair growth cycles.

research Evaluation of Personalized Skincare Through in-silico Gene Interactive Networks and Cellular Responses to UVR and Oxidative Stress

11 citations , October 2022 in “Clinical Cosmetic and Investigational Dermatology”

Personalized skincare can be improved by understanding genetic differences and using compounds like Resveratrol and Quercetin.

research Modulating the Antioxidant Response for Better Oxidative Stress-Inducing Therapies: How to Take Advantage of Two Sides of the Same Medal?

29 citations , March 2022 in “Biomedicines”

Enhancing antioxidant responses can improve treatments for various diseases.

research Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes

March 2026 in “The Journal of Steroid Biochemistry and Molecular Biology”

Deleting vitamin D and calcium receptors in skin cells increases skin cancer risk by reducing DNA repair and stress response.

research Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses

7 citations , January 2024 in “Cancer Research Communications”

research miR‐200a‐3p in Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Attenuates UVB‐Induced Skin Inflammatory Response and Oxidative Stress via Keap1‐Nrf2 Pathway

January 2025 in “Stem Cells International”

Exosomes from stem cells can reduce UV-induced skin damage by lowering inflammation and oxidative stress.

research The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

October 2022 in “Biomedicines”

Finasteride in male rats causes liver and metabolic issues in their offspring.

research Adult skin acute stress responses to short‐term environmental and internal aggression from exposome factors

37 citations , June 2021 in “Journal of the European Academy of Dermatology and Venereology”

Adult skin quickly reacts to short-term environmental and internal stress, leading to various skin issues and the need for protective measures.

Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 in a Growth- and Stress-Dependent Fashion

research Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion

30 citations , December 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

research Trichotillomania: a good response to treatment with N-acetylcysteine

27 citations , August 2017 in “Anais Brasileiros de Dermatologia”

N-acetylcysteine effectively treats trichotillomania.

research Dermal papilla cells and melanocytes response to physiological oxygen levels depends on their interactions

7 citations , June 2021 in “Cell Proliferation”

Low oxygen levels improve the function of hair and skin cells when they are in direct contact.

Effective Amelioration of Hepatic Inflammation and Insulin Response in High-Fat Diet-Fed Rats via Regulating AKT/mTOR Signaling: Role of Lepidium Sativum Seed Extracts

research Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

14 citations , October 2020 in “Journal of ethnopharmacology”

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Analysis of Changes in MicroRNA Expression Profiles in Response to the Troxerutin-Mediated Antioxidant Effect in Human Dermal Papilla Cells

research Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells

12 citations , May 2015 in “Molecular Medicine Reports”

Troxerutin helps protect skin cells from oxidative stress and may be good for treating hair loss.

research Reply to letter to the editor: “A response to ‘Male balding is a major risk factor for severe COVID-19’”

1 citations , October 2020 in “Journal of The American Academy of Dermatology”

Balding might help identify men at higher risk for severe COVID-19, but more research is needed.

research The effect of antioxidants administration on the response rate in patients with alopecia areata

December 2008 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ”

Antioxidants improved hair growth in alopecia areata patients regardless of disease duration.

research Understanding the biochemical properties of human hair keratins : self-assembly potential and cell response

January 2020

Human hair keratins can self-assemble and support cell growth, useful for biomedical applications.

Graphene Oxide and Indole-3-Acetic Acid Cotreatment Regulates the Root Growth of Brassica Napus L. via Multiple Phytohormone Pathways

research Graphene oxide and indole-3-acetic acid cotreatment regulates the root growth of Brassica napus L. via multiple phytohormone pathways

34 citations , March 2020 in “BMC plant biology”

Graphene oxide and indole-3-acetic acid together inhibit root growth in Brassica napus L. by affecting multiple plant hormone pathways.

research Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity

3 citations , January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells from people with Epidermolysis Bullosa Simplex have abnormally placed and less active mitochondria.

research Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts

32 citations , July 2017 in “Oncotarget”

Alternating treatment with two drugs could help cells in a rapid aging disease.

research Formation of the cornified envelope

3 citations , September 2005 in “Experimental dermatology”

The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.

research 519 The role of the leaky gut in the development of alopecia areata

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A compromised gut may trigger the autoimmune hair loss condition Alopecia Areata.

research Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile

January 2022 in “Figshare”

Autophagy helps mouse glands stay healthy, prevents early aging, and maintains their oil and scent production.

research Environmental Air Pollutants Affecting Skin Functions with Systemic Implications

70 citations , June 2023 in “International Journal of Molecular Sciences”

Air pollution harms skin health and can worsen skin diseases.

research Pathophysiology of the Behçet's Disease

34 citations , October 2011 in “Pathology Research International”

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

Gene Expression Profiling of Human Keratinocytes Exposed to the Hair-Dyeing Agent, m-Aminophenol

research The reduction of selenium(IV) by boreal Pseudomonas sp. strain T5-6-I – Effects on selenium(IV) uptake in Brassica oleracea

22 citations , August 2019 in “Environmental research”

Pseudomonas sp. T5-6-I bacteria increase selenium uptake in Brassica oleracea plants by 130%.

$Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing$

research Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing

20 citations , August 2022 in “Frontiers in Immunology”

Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.