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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

MC-1R is present in skin cells and may help reduce inflammation.

Researchers found a new gene area linked to male-pattern baldness, which, along with another gene, significantly increases the risk of hair loss in men.

Optimized liposomes can improve drug delivery and effectiveness.

Paroxetine relieves pain by increasing allopregnanolone levels.

The new synthetic retinoid RO 13-6298 effectively treated severe psoriasis at low doses with manageable side effects.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

A new type of hereditary hair loss in a Chinese family is linked to chromosome 2p25.1–2p23.2.

The specific skin disease variant p.(Arg2000Trp) in plectin can cause a wide range of symptoms, which should be considered when diagnosing patients.

OsPRX83 helps rice survive stress by improving stress response and antioxidant activity.

Pachyonychia congenita is linked to a keratin gene on chromosome 17.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Long-term oral and topical treatments improved skin condition in a goldendoodle with a genetic disorder.

Mrp3 may aid in wound healing and hair growth.

OsPHR3 can help breed rice that efficiently uses phosphate without growth issues.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

The peach gene pCTG134 helps control the interaction between auxin and ethylene hormones during fruit ripening.

Arab APS1 patients have unique and recurrent AIRE gene mutations.

Current drug safety systems fail to detect long-term side effects, needing improvements to protect health and trust.

A new gene mutation caused a man's rare skin condition, Schöpf-Schulz-Passarge syndrome.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.

Jieduquyuziyin prescription helps treat SLE with atherosclerosis by improving cholesterol removal and reducing inflammation.

Androgen receptors in the brain affect metabolism and reproduction differently in males and females, and may help manage PCOS symptoms in females.

The C-allele and CC-genotype in the PTPN22 gene lower the risk of alopecia areata.