research The JAK/STAT signaling pathway: from bench to clinic
The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
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240-270 / 1000+ results research Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application
Polymers can be designed to mimic natural cell environments for medical uses.
research Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells
Non-thermal plasma could help hair growth by activating key cell signals.
research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms
Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
research Induced pluripotent stem cells: Generation methods and a new perspective in COVID-19 research
iPSCs are promising for studying and treating COVID-19.
research iPSC-based approach for human hair follicle regeneration
The document concludes that using stem cells to regenerate hair follicles could be a promising treatment for hair loss, but there are still challenges to overcome before it can be used clinically.
research Types of Human Stem Cells and Their Therapeutic Applications
Stem cells can be reprogrammed for various treatments, but safety and expansion challenges remain.
research The role of WNT10B in physiology and disease: A 10-year update
WNT10B is important for body functions and linked to diseases like osteoporosis, obesity, and cancer.
research CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment
CD80 on skin stem cells helps expand Treg cells to aid wound healing.
research Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity
Stress can cause hair loss and trigger autoimmunity by damaging hair follicle cells.
research Keratin intermediate filaments in the colon: guardians of epithelial homeostasis
Keratin proteins are essential for keeping the cells in the human colon healthy and stable.
research Tracking adult stem cells
A combined approach is needed to fully understand adult stem cells, with genetic lineage-tracing being crucial.
research Pre‐clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer
Tryptanthrin effectively suppresses non-melanoma skin cancer and is safe for normal skin.
research Signal integrator function of CXXC5 in Cancer
CXXC5 can both suppress and promote cancer, making it a complex target for treatment.
research Changes in the proteomic profile of adipose tissue-derived mesenchymal stem cells during passages
Adipose stem cells show common protein changes as they grow, especially involving S100A6.
research EMT Factors and Metabolic Pathways in Cancer
EMT and metabolic pathways help cancer cells resist treatment and spread.
research Diverse Role of OX40 on T Cells as a Therapeutic Target for Skin Diseases
OX40-targeted therapies may help treat skin diseases by reducing inflammation and balancing immune responses.
research Plasticity of epithelial stem cells in tissue regeneration
Epithelial stem cells can adapt and help in tissue repair and regeneration.
research MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development
MiR-23b and miR-133 affect sheep hair growth by targeting specific genes.
research Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile
There are two types of stem cells in rodent hair follicles, each with different keratin proteins.
research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing
M-CSF-stimulated myeloid cells can turn into skin cells and help heal wounds and regrow hair.
research From Hair to Colon: Hair Follicle-Derived MSCs Alleviate Pyroptosis in DSS-Induced Ulcerative Colitis by Releasing Exosomes in a Paracrine Manner
Hair follicle stem cells can help treat ulcerative colitis in mice by releasing beneficial exosomes.
research Regeneration Genetics
Understanding tissue regeneration in animals can improve regenerative medicine.
research Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
research Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications
Biomimetic synthetic vesicles could improve precision medicine by combining natural and synthetic benefits.
research The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis
mTOR inhibitors may help treat lung fibrosis.
research Skin fibroblast functional heterogeneity in health and disease
Different types of skin fibroblasts have unique roles in skin health and disease.
research The Muscarinic Acetylcholine Receptor in Dermal Papilla Cells Regulates Hair Growth
Muscarinic acetylcholine receptors in skin cells help regulate and promote hair growth.
research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer
TGM3 is important for skin and hair structure and may help diagnose cancer.
research Fluorescence Microscopy—An Outline of Hardware, Biological Handling, and Fluorophore Considerations
Designing effective fluorescence microscopy experiments requires careful consideration of hardware, biological models, and imaging agents.