26 citations
,
April 2024 in “Particle and Fibre Toxicology” Nanoplastics can penetrate skin cells, triggering inflammation and immune responses.
45 citations
,
January 2021 in “Stem Cell Research & Therapy” The combination of stem cell medium and hydrogel effectively reduces and improves hypertrophic scars.
19 citations
,
September 2013 in “Molecular Medicine Reports” Human hair follicle stem cells can become smooth muscle cells using specific growth factors.
31 citations
,
March 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.
7 citations
,
June 2020 in “npj regenerative medicine” GDNF helps grow hair and heal skin wounds by acting on hair stem cells.
4 citations
,
June 1998 in “The Journal of Clinical Endocrinology & Metabolism” KGF and its receptor are found in enlarged prostate tissue and KGF strongly increases cell growth.
3 citations
,
November 2019 in “Journal of Investigative Dermatology” Adenosine helps human hair grow and prevents hair loss by targeting specific cells.
47 citations
,
October 2016 in “Molecular and Cellular Endocrinology” Androgens prevent hair growth by changing Wnt signals in cells.
98 citations
,
February 2007 in “Seminars in Cell & Developmental Biology” Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.
32 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” 17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.
8 citations
,
April 2020 in “Journal of Ethnopharmacology” Herbs might help with hair loss, but more research is needed to confirm their safety and effectiveness.
5 citations
,
January 2017 in “Endocrinology” Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.
The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.
January 1995 in “Adolescent and pediatric gynecology” Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.
1533 citations
,
October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
249 citations
,
November 2003 in “Clinical endocrinology” Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
11 citations
,
July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS” Estrogens are key for bone growth spurts in both boys and girls and affect growth into adulthood.
6 citations
,
November 2020 in “Molecular and Cellular Endocrinology” Androgens reduce BMP2, which weakens the ability of certain cells to help hair stem cells become different types of cells.
4 citations
,
February 2021 in “Nano select” MSC-Exos can aid organ development and offer therapeutic benefits for various conditions.
185 citations
,
June 2011 in “Molecular and cellular endocrinology” Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
163 citations
,
March 2012 in “BMC biology” Stem cell niches support, regulate, and coordinate stem cell functions.
159 citations
,
October 2015 in “Science Advances” Blocking JAK-STAT signaling can lead to hair growth.
159 citations
,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
134 citations
,
January 2010 in “Biomedical research” Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.
84 citations
,
October 2014 in “PLoS Genetics” Wnt signaling is essential for forming the skin's spinous layer through a BMP-FGF pathway.
63 citations
,
October 2013 in “Dermatologic Surgery” Platelet-Rich Plasma (PRP) increases the number of new hair follicles and speeds up hair formation.
60 citations
,
September 2001 in “Journal of the American Academy of Dermatology” Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.
56 citations
,
August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” Different women's hair and skin glands respond to hormones in varied ways, which can cause unwanted hair growth even with normal hormone levels, and more research is needed to treat this effectively.
53 citations
,
October 2012 in “The FASEB Journal” Bimatoprost, a glaucoma medication, may also help treat hair loss.
36 citations
,
January 2014 in “Elsevier eBooks” The skin is a complex barrier that protects the body, regulates temperature, and helps with immune responses.