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GlossaryParonychia

infection around nails causing redness, swelling, and pain

Paronychia is an infection of the skin around the nails, typically caused by bacteria or fungi. It leads to redness, swelling, and pain around the nail, and in some cases, pus may form. This condition can be acute, developing rapidly, or chronic, persisting for weeks or longer, often due to repeated exposure to moisture or irritants.

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research The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome

90 citations , August 2006 in “British Journal of Dermatology”

PRIDE syndrome includes skin and hair issues from cancer treatment with EGFR inhibitors.

PRIDE Complex: Papulopustules, Paronychia, Hair Growth Abnormalities, Itching, and Dryness Due to EGFR Inhibitors

research PRIDE Complex (Papulopustules and/or Paronychia, Regulatory Abnormalities of Hair Growth, Itching, Dryness Due to EGFR Inhibitors)

August 2025 in “JEADV Clinical Practice”

PRIDE complex side effects from EGFR inhibitors can be managed without stopping treatment.

research Dacomitinib-Induced Paronychia Associated With PRIDE Syndrome in a Patient With Non-Small Cell Lung Cancer

June 2025 in “Cureus”

Dacomitinib can cause nail and skin issues, but these can be managed without stopping the drug.

research A linear and reticulate crusted keratotic papulopustular eruption: a rare presentation of PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) complex

August 2024 in “Postgraduate Medical Journal”

A rare skin reaction from cancer treatment was successfully managed with topical treatments and antihistamines.

research Povidone-iodine nail solution is active in treating chemotherapy-associated paronychia

May 2015 in “Journal of The American Academy of Dermatology”

Povidone-iodine nail solution effectively treats nail infections caused by chemotherapy.

research Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

508 citations , June 2009 in “Current drug metabolism”

Tyrosine kinase inhibitors effectively treat cancers but often cause skin and other side effects.

research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor

116 citations , December 2003 in “Acta Dermato Venereologica”

Iressa often causes skin issues like acne and dryness in lung cancer patients.

research Dermatologic adverse events associated with afatinib: an oral ErbB family blocker

87 citations , March 2013 in “Expert Review of Anticancer Therapy”

Afatinib often causes skin problems that need proactive management.

research Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management

68 citations , January 2014 in “Dermatology research and practice”

Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.

research Dermatological side effects of epidermal growth factor receptor inhibitors: ′Pride′ complex

43 citations , January 2014 in “Indian Journal of Dermatology”

EGFR inhibitors can cause skin issues like acne and dryness, but these can be managed without stopping treatment.

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

42 citations , April 2012 in “Seminars in Oncology”

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

research Cutaneous side-effects of EGFR inhibitors and their management.

38 citations , January 2011 in “PubMed”

EGFR inhibitors often cause skin issues like acne and dryness, which can be managed with specific treatments.

research Alopecia Associated with Indinavir Therapy

38 citations , August 1999 in “New England journal of medicine/The New England journal of medicine”

Indinavir can cause hair loss and other skin problems.

research The management of EGFR inhibitor adverse events: a case series and treatment paradigm

32 citations , January 2012 in “International Journal of Dermatology”

Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.

research Bacterial Diseases of the Skin

29 citations , January 2005 in “Journal of Long-Term Effects of Medical Implants”

Nonbullous impetigo is the most common bacterial skin infection in children, often needing treatment to prevent complications.

research Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities

22 citations , March 2017 in “Journal of the Formosan Medical Association”

The guidelines help doctors manage skin problems from certain cancer treatments to improve patients' lives.

research Cutaneous reactions to targeted therapies in children with CNS tumors: A cross‐sectional study

16 citations , February 2019 in “Pediatric Blood & Cancer”

Most children with CNS tumors on targeted therapy had skin reactions, which were generally treatable without stopping the therapy.

research Dermatologic Effects of Selumetinib in Pediatric Patients with Neurofibromatosis Type 1: Clinical Challenges and Therapeutic Management

15 citations , March 2024 in “Journal of Clinical Medicine”

Selumetinib causes skin and hair side effects in kids with NF1, affecting treatment and quality of life.

research Erosive pustular dermatosis of the scalp induced by gefitinib: case and review of the literature

5 citations , January 2021 in “Dermatology Online Journal”

An 84-year-old man developed a rare scalp condition from a cancer drug but continued treatment as it was otherwise well tolerated.

research Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.

5 citations , April 2016 in “PubMed”

Cetuximab often causes skin problems, but they can be managed without stopping treatment.

research A novel approach to manage skin toxicity caused by therapeutic agents targeting epidermal growth factor receptor

4 citations , March 2012 in “Annals of oncology”

New treatment with green tea polyphenols and nicotinamide improves skin problems from cancer therapy.

research “PRIDE” Complex

3 citations , January 2019 in “Indian Journal of Drugs in Dermatology”

Certain cancer drugs can cause skin issues like rashes and itching.

research Cutaneous Adverse Events of Targeted Anticancer Therapy: A Review of Common Clinical Manifestations and Management

2 citations , December 2015 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Targeted anticancer therapies often cause skin issues, affecting treatment adherence and quality of life.

research Continuous MEK inhibition by AZD6244 (ARRY-142886) results in exhaustion of the cutaneous keratinocytic stem cell pool and resembles senescence driven skin aging

2 citations , May 2008 in “Journal of Clinical Oncology”

AZD6244 treatment causes skin aging effects by depleting skin stem cells.

Targeted Treatments of Non-Small Cell Lung Cancer: Skin Toxicity

research Targeted Treatments of Non-Small Cell Lung Cancer (NSCLC): Skin Toxicity

1 citations , October 2022 in “Дерматовенерология Косметология”

EGFR inhibitors for lung cancer can cause severe skin issues.

research Skin Signs of Zinc Deficiency in Children: A clinical study in Jordan.

1 citations , January 2019 in “Jordan Medical Journal”

Zinc deficiency in children can cause skin issues and is often overlooked.

Pharmacotherapy of Plexiform Neurofibromas in Patients with Neurofibromatosis Type 1: Possible Adverse Events and Their Management

research Pharmacotherapy of plexiform neurofibromas in patients with neurofibromatosis type 1. Possible adverse events and their management

July 2024 in “Russian Journal of Child Neurology”

Selumetinib effectively reduces tumor size in many children with neurofibromatosis type 1, but can cause skin and hair issues.

research Acrodermatitis enteropathica – diagnostic challenges

February 2023 in “Research Square (Research Square)”

Genetic testing confirmed a rare skin disorder in a young girl, which improved with zinc supplementation.

research PRIDE syndrome with lumbosacral hypertrichosis

January 2022 in “Dermatology Review”

EGFR inhibitors can cause unusual localized hair growth.

PRIDE Syndrome: A Practical Way to Identify Adverse Skin Effects of EGFR Inhibitors

research Síndrome PRIDE: una práctica forma de identificar los efectos adversos cutáneos de los inhibidores del EGFR

October 2021 in “Revista Medicina Cutánea Ibero-Latino-Americana”

PRIDE syndrome helps identify skin side effects from EGFR inhibitors like erlotinib.