research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
PADI4 enzyme slows down cell growth in developing hair follicles.
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research 15-Hydroxyprostaglandin Dehydrogenase Inhibitor Restores Endothelial Function Under Dihydrotestosterone-Induced Stress in Human Dermal Microvascular Endothelial Cells
DPP may help hair regrowth by improving blood vessel function under stress.
research Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.
Four-amino acid part makes enzyme sensitive to finasteride.
research Does prostaglandin D2 hold the cure to male pattern baldness?
Prostaglandin D₂ might be targeted for new male pattern baldness treatments.
research The prevention of benign prostatic hyperplasia (bph)
A vaccine may prevent benign prostatic hyperplasia (BPH).
research Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS)
These medications for BPH have known risks and may have new side effects.
research Prostaglandin D 2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
PGD2 stops hair growth and is higher in bald men with AGA.
research New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors
New compounds may help treat prostate issues without affecting androgen receptors.
research Methylated CpG dinucleotides in 5-α reductase 2 gene might explain the finasteride-resistance in BPE patients
Methylated gene parts may cause finasteride-resistance in some enlarged prostate patients.
research Trimodal Mini‐Invasive Therapy for Stable‐Phase Peyronie's Disease: A Two‐Center Real‐Life Prospective Pilot Study
PRP injections are safe but don't significantly improve Peyronie's Disease.
research Literature Review: Finasteride and Persistent Erectile Dysfunction (PED)
research LPA-producing enzyme PA-PLA1α regulates hair follicle development by modulating EGFR signalling
The enzyme PA-PLA1α is important for proper hair follicle development.
research The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin‐1 (PN‐1) inhibition
CAP1/Prss8 does not activate PAR2 or inhibit PN-1.
research Pharmacological Approaches in Managing Symptomatic Relief of Benign Prostatic Hyperplasia: A Comprehensive Review
Tadalafil is effective for treating urinary symptoms in men with BPH.
research Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review
Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.
research Finasteride interferes with prostaglandin-induced CatSper signalling in human sperm
Finasteride may affect male fertility by interfering with specific sperm signaling.
research (122) Erectile Hemodynamics Asessment In ED Patients With Self-Diagnosed Post-finasteride syndrome (PFS)
Men with self-diagnosed PFS-related ED have normal erectile hemodynamics.
research Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish
Pvalb8 is essential for zebrafish hearing and hair cell development, and its mutation causes hearing loss.
research RP-HPLC-Based Stability-Indicating Analytical Method for Concurrent Determination of Finasteride and Tadalafil: Development and Validation
A reliable method was developed to measure Finasteride and Tadalafil together, showing they degrade under certain conditions.
research Segregation of Incomplete Achromatopsia and Alopecia Due to PDE6H and LPAR6 Variants in a Consanguineous Family from Pakistan
Genetic variants in PDE6H and LPAR6 cause vision impairment and hair loss in two Pakistani brothers.
research Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation
Two peptides, RMYYY and VMYMI, may be effective anti-inflammatory drugs.
research Dutasteride/finasteride
research 1492 Prostacyclin pathway to enhance wound healing in diabetic foot ulcers
Treprostinil, a drug, can delay wound healing in healthy cells but doesn't affect diabetic foot ulcer cells, suggesting further research could help understand its role in treating these ulcers.
research Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase
The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.
research A novel EDA variant that causes X-linked hypohidrotic ectodermal dysplasia in a Chinese family
This study presents a case of a Chinese family where a novel EDA gene variant (c.806G > T, p.Gly269Val) was identified as causing X-linked hypohidrotic ectodermal dysplasia (XLHED). A prenatal ultrasound at 23 weeks gestation revealed signs of the disorder, leading to the decision to terminate the pregnancy. The diagnosis was confirmed post-abortion through Sanger sequencing of fetal tissue. The findings highlight the effectiveness of prenatal ultrasonography in screening for ectodermal dysplasia and expand the known range of EDA variants, aiding in accurate diagnosis and informed reproductive choices for potential patients.
research The physiological and pharmacological roles of prostaglandins in hair growth
Targeting the PGD2-DP2 pathway may help treat hair loss.
research Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride
Using finasteride or dutasteride may cause long-lasting erectile dysfunction.
research Finasteride to treat recurrent priapism in sickle cell anemia
research Are finasteride-related penile curvature/Peyronie’s disease Adverse Event Reports worthy of further clinical investigation? Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases
Finasteride may be linked to Peyronie’s disease, but more research is needed.