212 citations
,
January 2017 in “Mediators of Inflammation” Stem cells show promise in speeding up wound healing and tissue regeneration.
160 citations
,
January 2014 in “Seminars in cell & developmental biology” Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.
149 citations
,
July 2017 in “PLoS Biology” Hair follicle patterns form through a mix of self-organization and signaling interactions.
147 citations
,
November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
146 citations
,
July 2018 in “Regenerative Medicine” Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.
142 citations
,
March 2019 in “Molecules/Molecules online/Molecules annual” Cannabinoids may help treat various skin conditions.
138 citations
,
June 2012 in “Genes & Development” Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.
133 citations
,
July 2020 in “Cells” Creating fully functional artificial skin for chronic wounds is still very challenging.
131 citations
,
May 2015 in “Experimental Dermatology” Microneedles help improve skin appearance and deliver skin treatments effectively, but safety concerns need more research and regulation.
128 citations
,
October 2011 in “Development” Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
124 citations
,
November 2019 in “International Journal of Molecular Sciences” Standardized kits improve the quality and consistency of isolating stem cells from fat tissue.
119 citations
,
March 2020 in “Frontiers in Bioengineering and Biotechnology” Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.
116 citations
,
April 2020 in “Stem Cell Research & Therapy” Wharton's jelly stem cells show diverse traits and functions.
115 citations
,
August 2020 in “International Journal of Molecular Sciences” A PRP concentration of 1.0 × 10^6 plt/μL is best for tissue repair.
115 citations
,
December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
114 citations
,
February 2023 in “International Journal of Molecular Sciences” The skin microbiome is crucial for skin health, and more research is needed to explore its role and potential treatments.
108 citations
,
August 2017 in “Clinical, Cosmetic and Investigational Dermatology” Microneedling is promising for treating various skin issues but needs more research to confirm its effectiveness and safety.
97 citations
,
March 2009 in “Dermato-endocrinology” Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.
92 citations
,
March 2016 in “Developmental Cell” Zebrafish skin regeneration relies on cell behaviors and reactive oxygen species, with antioxidants reducing and hydrogen peroxide increasing regeneration.
88 citations
,
July 2020 in “Frontiers in Cell and Developmental Biology” Bioengineered materials improve wound healing by releasing growth factors and cytokines more effectively than traditional methods.
87 citations
,
September 2014 in “International Journal of Molecular Sciences” FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.
82 citations
,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
81 citations
,
March 2022 in “Frontiers in Bioengineering and Biotechnology” Bioengineered scaffolds help heal skin wounds, but perfect treatments are still needed.
80 citations
,
September 2007 in “Cell Cycle” Stem cells in hair follicles can become various cell types, including neurons.
79 citations
,
January 2019 in “International Journal of Molecular Sciences” Burn injuries in mice heal similarly to humans, with inflammation and cell changes normalizing over time.
75 citations
,
August 2018 in “Biochemical pharmacology” Targeting the skin's endocannabinoid system could help treat skin disorders.
72 citations
,
November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
70 citations
,
February 2017 in “Dermatologic Surgery” Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.
67 citations
,
December 2011 in “Stem Cells and Development” NADPH oxidase 4 is key for stem cell activity and growth under low oxygen.
65 citations
,
May 2017 in “Advances in wound care” Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.