January 2026 in “International Journal of Innovative Technologies in Social Science” Zinc is crucial for health, and deficiency can lead to immune, digestive, skin, and metabolic issues.
12 citations
,
February 1986 in “PubMed” Injecting newborn mice with a niacin blocker caused skin, gut, and brain damage similar to human pellagra.
10 citations
,
November 1946 in “Journal of the American Medical Association” Severe vitamin deficiencies in children can cause significant hair problems.
7 citations
,
March 1931 in “Experimental Biology and Medicine” Iron deficiency causes hair loss in white rats and mice.
October 2019 in “Postgraduate Medical Journal” Pellagrous dermatitis, caused by niacin deficiency, can be cured with vitamin supplements.
June 1937 in “Science news-letter/Science news letter” Vitamin B can prevent hair from turning gray in rats.
10 citations
,
September 1994 in “International Journal of Dermatology” Three Iranian men had reddish-brown facial pigmentation with no effective treatment.
2 citations
,
October 2016 in “Nutrition in clinical practice” Vitamin B12 deficiency can cause facial dark spots that go away with treatment.
11 citations
,
August 1986 in “Archives of Dermatology” Vitamin B12 deficiency can cause skin and hair color changes, which can be reversed with treatment.
1 citations
,
September 2017 in “BMJ” The man has a disease causing skin patches, thickened nerves, and mild muscle weakness.
16 citations
,
February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
7 citations
,
January 2008 in “Indian Journal of Dermatology” Pigmentary mosaicism causes skin color changes and can affect multiple body systems, but has no cure.
77 citations
,
August 1986 in “Archives of Dermatology” Vitamin B12 deficiency can cause skin and hair color changes, which are reversible with treatment.
June 2021 in “Asian Journal of Medical Sciences” Vitamin B12 deficiency can cause reversible skin darkening.
November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” Valproic acid can cause dark lines on nails.
9 citations
,
November 2015 in “JAMA dermatology” A 91-year-old woman's hair turned black in one spot, with skin changes underneath.
June 2023 in “International Journal of Dermatology” Lichen planus pigmentosus mainly affects middle-aged women with darker skin, is underreported, and is hard to treat.
94 citations
,
October 2017 in “International Journal of Dermatology” Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.
5 citations
,
August 2015 in “Sultan Qaboos University medical journal” Vitamin B12 deficiency can cause skin darkening and other symptoms, which improve with B12 supplements.
4 citations
,
November 2019 in “Dermatology - Open Journal” Lichen planus pigmentosus is hard to treat and may be more common in North Africa than previously thought.
5 citations
,
July 2009 in “Clinical and experimental dermatology” 3 citations
,
January 2016 in “Dermatology online journal” Some people with lichen planus pigmentosus might later develop frontal fibrosing alopecia.
4 citations
,
March 2020 in “JAAD Case Reports” Vitamin B12 deficiency can cause darkening of all nails.
August 2024 in “Journal of the American Academy of Dermatology” Nail color change might be an early sign of skin pigmentation from minocycline.
1 citations
,
April 2015 in “Neurology” Skin pigmentation increases in CRPS-affected areas and improves with symptom relief.
10 citations
,
June 2011 in “Archives of Dermatology” Finasteride caused blisters on hands and feet.
February 2023 in “Indian journal of private psychiatry/Indian Journal of Private Psychiatry” Valproic acid can rarely cause reversible nail discoloration.
9 citations
,
July 2012 in “Dermatitis” Hair dye with para-phenylenediamine can cause skin depigmentation.
October 2019 in “European Journal of Dermatology” The boy's hair and skin color differences are due to a pigmentation disorder.