research Hormesis and medicine
Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
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research Repurposing FDA approved drugs for psoriasis indications through integrated molecular docking, one-SVM algorithm, and molecular dynamics simulation approaches
Pioglitazone, Trimipramine, and Dimetindene may be repurposed to treat psoriasis.
research Organoid‐Guided Precision Medicine: From Bench to Bedside
Organoid technology is improving personalized medicine by better predicting drug responses and treatments.
research Modeling Dynamic Hair as a Continuum
The authors created a realistic and efficient method to simulate hair movement by combining fluid dynamics with individual hair strand behavior.
research Explaining and predicting the single channel versus multi-channel consumer: the case of an embarrassing product
The Theory of Planned Behaviour predicts consumer behavior better when emotions, personality, demographics, and marketing are included.
research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles
The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.
research The cycling hair follicle as an ideal systems biology research model
The hair follicle is a great model for research to improve hair growth treatments.
research Case-Only Trees and Random Forests for Exploring Genotype-Specific Treatment Effects in Randomized Clinical Trials with Dichotomous End Points
Case-only trees and random forests improve predictions of treatment effects in clinical trials.
research DNN-DTIs: improved drug-target interactions prediction using XGBoost feature selection and deep neural network
The DNN-DTIs method accurately predicts drug-target interactions and is useful for drug repositioning.
research 397 Predictive modeling of drug response and mechanism of action in alopecia areata clinical trials
Researchers found three different ways drugs work to treat hair loss from alopecia areata and identified key factors for personalized treatment.
research Pentoxifylline-Loaded Liposome Development, Characterization, and In Vitro Release Kinetics: Box-Behnken Design-Based Optimization.
Optimized liposomes can improve drug delivery and effectiveness.
research BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
A reliable method was developed to measure Finasteride and Tadalafil in rat blood.
research Aspect-Level Drug Reviews Sentiment Analysis Based on Double BiGRU and Knowledge Transfer
A model called PM-DBiGRU was developed for analyzing sentiments in drug reviews, and it performed better than other models, but struggled with complex sentences and situations requiring background knowledge.
research Combination Therapies and the Theoretical Limits of Evidence-Based Medicine
The current system can't fully test all combination treatments, so alternative methods and regulatory flexibility are needed.
research Biochemical approach on the conservation of drug molecules during hair fiber formation
Drugs can be incorporated into hair based on their chemical properties and hair pigmentation.
research Agglomerative clustering-based drugs graded for the risk signals of drug-induced cognitive disorder: a study on the FAERS database
Finasteride is high-risk for cognitive disorders, while Carbidopa/Levodopa, Topiramate, and Clonazepam are moderate-risk.
research Modeling the dynamics of human hair cycles by a follicular automaton
The model accurately simulates human hair growth and hair loss patterns.
research The biphasic regulatory effect of diphencyprone on mouse hair growth and its relation to protein kinase C isoforms
Diphencyprone initially increases mouse hair growth, then slows it, possibly due to changes in specific protein levels.
research Peer Review #2 of "Computational drug repositioning based on side-effects mined from social media (v0.1)"
Reviewers suggested the study on finding new drug uses through social media side-effects needs better methods and clearer limitations.
research Clinically relevant skull models and optical measurement method to evaluate programmable hydrocephalus valve tool kit usability
Three skull models were found most useful for testing hydrocephalus valve programming.
research Why Do Promising Therapies Stall in Development and How Can We Move Them Forward?
Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.
research Past and Future Strategies for GPCR Deorphanization
Finding functions for unknown GPCRs is hard but key for making new drugs.
research A Temporal Mathematical Model of Alopecia Areata: Investigating Hair Cycle Dynamics and Disease Progression
The model helps understand alopecia areata and suggests ways to improve treatment by targeting immune issues.
research Mixing the Old with the New: Drug Repurposing for Immune Deficiency in the Era of Precision Medicine and Pediatric Genomics
Using old drugs for new uses can help treat rare immune deficiencies.
research 706 Predictive modeling of patient response to JAK/STAT inhibitors and dynamic patient-matching
Machine learning can predict how well patients with alopecia areata will respond to certain treatments.
research Modeling and Simulation of X-Rays Radiotherapy
Microbeam Radiation Therapy is effective, but using a linear accelerator reduces its benefits.
research Spotlight Commentary: Importance of dose redefining in the process of drug repurposing
Redefining drug dosages is crucial when repurposing them for new uses.
research Abstracts
The model helps improve medical devices by showing how skin deforms under pressure.
research Experimental Models and Molecular Pathogenesis: An Integrated Review of Alopecia
Current models for studying alopecia are inadequate, and more human-like systems are needed.
research Proposed ICD-10 framework for identifying emergency department visits that may be impacted by community pharmacy care clinics
Pharmacy care clinics can reduce some emergency visits by managing certain conditions and medication issues.