research Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.2)"
The study improved and was accepted despite initial concerns about data clarity, methodology, and potential overfitting.
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research Modelling of the composition of emulsion medicines and cosmetics stabilized by a biocomplex of surfactant substances based on rhamnolipids Pseudomonas sp. PS-17
A semi-automated system can effectively help choose emulsion ingredients, simplifying the creation of medicinal and cosmetic products.
research A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease
The study developed a 3D model that closely imitates remaining ovarian cancer after treatment and identified a potential drug targeting resistant cancer cells.
research Open and Closed Structure
The 3D hair follicle model improves understanding of hair growth and drug testing.
research Integrated edge information and pathway topology for drug-disease associations
iEdgePathDDA effectively finds new drug-disease links, outperforming other methods.
research Increasing the solubility of minoxidil using a mixture of 1-propanol and water by the shake flask method: experimental measurements, thermodynamic analyses, and mathematical modeling
research Machine Learning--Enhanced Pharmacovigilance Assessment of Cardiac Adverse Events Associated With Minoxidil
Minoxidil is strongly linked to heart problems, and machine learning can improve drug safety checks.
research Drug repurposing: Clinical practices and regulatory pathways
Drug repurposing offers faster, cheaper drug development but faces challenges like safety, ethics, and funding.
research Machine Learning Applications for Drug Repurposing
Machine learning helps find new uses for existing drugs, improving healthcare.
research Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer
3D-bioprinting models of pancreatic cancer could help personalize treatments but need more testing.
research Modeling the dynamics of human hair cycles by a follicular automaton
The model successfully simulates human hair growth and patterns, including hair loss types.
research Dodatek A: Model matematyczny AL/RC/ASE. Functional Androgen Axis (FOA) - wersja operacyjna v1.2
The model improves understanding of androgen interactions by focusing on signal intensity and system capacity.
research An open-access data set of pig skin anatomy and physiology for modelling purposes
The data set helps improve predictions of how substances are absorbed through pig skin.
research Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model
50-mg ritlecitinib capsules are bioequivalent to 100-mg capsules.
research Dodatek A: Model matematyczny AL/RC/ASE. Functional Androgen Axis (FOA) - wersja operacyjna v1.2
The model improves understanding of androgen interactions by focusing on signal intensity and system capacity.
research Preformulation studies of finasteride to design matrix systems for topical delivery
research Hair keratin molecular dynamics studies
Simulations of hair keratin help improve disease treatment and cosmetic products.
research Community Detection and Patient Experience Analysis in Reddit Conversations on Janus Kinase Inhibitors using Large Language Models
A few users dominate Reddit discussions on JAK inhibitors, highlighting social media's potential for tracking drug safety but needing expert oversight.
research Can an in vitro hair drug model be developed using dermal papilla cells alone?
Dermal papilla microtissues could be useful for initial hair growth drug testing.
research Drug Repurposing: Accelerating New Therapeutic Discoveries from Old Molecules (1990 – 2025)
Repurposing existing drugs can quickly and cheaply find new treatments.
research Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.3)"
Reviewers criticized the study's methods and suggested focusing on drug mechanisms instead of repositioning due to social media data quality concerns.
research Drug Repurposing: Accelerating New Therapeutic Discoveries from Old Molecules (1990 – 2025)
Drug repurposing finds new uses for old drugs quickly and cheaply.
research Modeling of ionizing radiation induced hair follicle regenerative dynamics
Hair follicles can regenerate after radiation damage but not during a specific growth phase.
research The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs
The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.
research A probabilistic Boolean model on hair follicle cell fate regulation by TGF-β
TGF-β and TNF influence hair follicle cell fate, with TNF being more effective in triggering cell death.
research APLICAÇÃO DE PLANEJAMENTO DE EXPERIMENTOS (DoE) PARA OTIMIZAÇÃO DE MÉTODO ANALÍTICO PARA QUANTIFICAÇÃO DE MINOXIDIL POR CLAE
Optimizing the method improved minoxidil measurement accuracy and efficiency.
research Innovations in skin microphysiological systems for nonclinical testing and FDA modernization
New technologies replicate human skin for testing without animals.
research Understanding the formation mechanism of drug-polymer inclusion complex by structure elucidation and theoretical calculation
The research found how certain drugs and polymers form stable complexes, which could help develop new pharmaceutical forms.
research A computational approach to mechanistic and predictive toxicology of pesticides
Pesticides can cause reproductive and adrenal health issues.
research Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling
The model helps understand and improve treatments for alopecia areata by simulating hair growth and immune cell interactions.