research Effectiveness of short term canrenone treatment in idiopathic hirsutism.
Canrenone effectively reduced hair growth and testosterone levels in women with excessive hairiness.
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research Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase
Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.
research Eflornithine Cream Combined with Laser Therapy in the Management of Unwanted Facial Hair Growth in Women
Combining eflornithine cream with laser therapy effectively reduces unwanted facial hair in women.
research A fixed-dose combination of finasteride and tadalafil (Entadfi) for BPH.
Entadfi, a mix of finasteride and tadalafil, is used for BPH.
research Torilin fromTorilis japonica,as a New Inhibitor of Testosterone 5α-Reductase
Torilin from Torilis japonica can inhibit testosterone 5α-reductase but is less effective than finasteride.
research Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase
Phyllanthus urinaria extract may help treat hair loss by blocking a hair-related enzyme.
research New Aromatic Esters of Progesterone as Antiandrogens
New progesterone-based compounds can block male hormones.
research Regulation of immune response genes in the skin of allergic and clinically tolerant individuals exposed to p‐phenylenediamine
Everyone has an immune response to PPD, but reactions differ, causing tolerance, mild inflammation, or allergy.
research Cholesterol and Phospholipid-free Multilamellar Niosomes Regulate Transdermal Permeation of a Hydrophobic Agent Potentially Administrated for Treating Diseases in Deep Hair Follicles
Cholesterol- and phospholipid-free niosomes improve deep skin drug delivery.
research Investigation of intermolecular interactions in finasteride drug crystals in view of X-ray and Hirshfeld surface analysis
Finasteride crystals are held together by hydrogen bonds and weak interactions, forming synthon pseudopolymorphs.
research How safe and effective is finasteride for hair loss in postmenopausal women?
Finasteride at 1 mg daily doesn't help hair loss in postmenopausal women and has similar side effects to a placebo.
research 5α‐reductase inhibitors: Evaluation of their potential confounding effect on GC‐C‐IRMS doping analysis
5α-reductase inhibitors can interfere with doping tests by masking banned substances.
research 176 Characterising Neurotransmitter Signalling in Human Skin and Hair Follicles
Skin and hair cells release serotonin and histamine naturally, which could help improve skin health.
research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
research Novel acne cream seeks FDA approval
A new acne cream effectively reduced acne in trials and awaits FDA approval.
research Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach
The new gel formula could improve the delivery of a hair loss treatment through the skin and might be an alternative to taking it by mouth.
research Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling
Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.
research Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome
Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.
research Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study
The oral supplement with Pinus pinaster and Grape seed extract, used with sunscreen, effectively and safely improved mild-to-moderate facial melasma.
research Mast cell-5-HT-HTR2A axis involvement in chronic itch induced by SADBE
Targeting the MC-5-HT-HTR2A axis may help treat chronic itching.
research SAT378 Unusual Case of Hirsutism From Prolactinoma Induced Dihydrotestosterone Elevation
A woman's excessive hair growth was linked to a rare case of high testosterone caused by a prolactin-producing pituitary tumor.
research Nigella sativa and its nano‐mediated approach toward management of neurodegenerative disorders: A review
Black cumin and its nanoformulations show promise in treating neurodegenerative diseases.
research Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment.
Niacin deficiency makes rats more sensitive to cancer-causing chemicals.
research Does Nirmatrelvir/Ritonavir Influence the Immune Response against SARS-CoV-2, Independently from Rebound?
Nirmatrelvir/Ritonavir treatment may lead to a weaker immune response to COVID-19, but doesn't affect the chance of rebound.
research Medical treatment of hirsutism
The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.
research Successful Treatment of Hirsutism in HAIR-AN Syndrome Using Flutamide, Spironolactone, and Birth Control Therapy
The document describes a treatment for excessive hair growth in a teenage girl using medication and birth control, but does not report the results.
research Ultra-low dose estradiol and dydrogesterone for the treatment of menopausal symptoms in a pooled, multi-ethnic population
The study evaluated the efficacy of an ultra-low dose combination of 0.5 mg estradiol and 0.25 mg dydrogesterone in alleviating vasomotor symptoms in a multi-ethnic population of 583 postmenopausal women from Europe and China. Participants were randomized to receive the treatment or a placebo for 12 weeks. Results showed a significant reduction in the number of hot flushes per day with the treatment compared to placebo, along with improvements in health-related quality of life, including psychological symptoms and vaginal dryness. The treatment was well tolerated, with no significant differences in serious adverse events or changes in body weight between the groups. The study concludes that this treatment is consistently effective for menopause-related symptoms across different ethnicities.
research Administration of finasteride modulates depressive-like behavior in the forced swim task of male rats
research Development and optimization of finasteride-cinnamon oil-loaded ethanol-free microemulsions for transdermal delivery
The optimized microemulsion with cinnamon oil effectively delivers finasteride through the skin without damaging hair.
research Steroid 5α-reductase inhibition by polymethoxyflavones
Certain natural compounds can block an enzyme linked to prostate enlargement and hair loss, showing potential for new treatments.