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GlossaryPhosphatidic Acid

lipid molecule involved in cell membrane structure and signaling

Phosphatidic Acid (PA) is a type of lipid molecule that plays a crucial role in the structure and function of cell membranes. It acts as a precursor for the biosynthesis of other lipids and is involved in cell signaling pathways that regulate various cellular processes, including growth and metabolism.

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Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

research Phosphatidic Acid Has a Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

46 citations , August 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Phosphatidic acid may help hair grow by affecting cell growth pathways.

research Studies on the biological actions of procyanidins and phosphatidic acids on the hair follicles : experimental approaches

January 2006

Procyanidins and phosphatidic acids help promote hair growth.

Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

research Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

38 citations , June 2018 in “Plant & cell physiology/Plant and cell physiology”

Changing the amount of PLC5 in Arabidopsis affects root growth and drought resistance, with less PLC5 slowing root growth and more PLC5 improving drought tolerance but hindering root hair growth.

research Exploration of potential lipid biomarkers for premature canities by UPLC‐QTOF‐MS analyses of hair follicle roots

7 citations , June 2020 in “Experimental dermatology”

Researchers found that certain lipids, especially vitamin D3, are lower in prematurely grey hair than in pigmented hair.

research In This Issue

August 2003 in “Journal of Investigative Dermatology”

Phosphatidic acid may promote hair growth like minoxidil.

research TRADITIONAL USES, PHYTOCHEMISTRY, AND PHARMACOLOGICAL ACTIVITIES OF AMLA WITH SPECIAL REFERENCE OF UNANI MEDICINE - AN UPDATED REVIEW

2 citations , January 2019 in “Asian journal of pharmaceutical and clinical research”

Amla is a natural remedy with many health benefits, including antiviral and antibacterial properties.

research PHOSPHATIDES IN MOUSE EPIDERMIS UNDERGOING NORMAL AND ABNORMAL GROWTH CHANGES.

13 citations , April 1964 in “PubMed”

Phosphatide distribution in mouse skin remains consistent in both normal and cancerous growths.

research A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis

280 citations , January 2004 in “The EMBO Journal”

AGC2-1 protein is essential for root hair growth in Arabidopsis.

research Lipid signalling in plant responses to abiotic stress

646 citations , October 2015 in “Plant Cell & Environment”

Lipids help plants respond to stress by triggering important signals.

research Molecular characterization of GhPLDα1 and its relationship with secondary cell wall thickening in cotton fibers

13 citations , October 2016 in “Acta Biochimica et Biophysica Sinica”

GhPLDα1 helps thicken cotton fiber walls by boosting cellulose production.

research LPA3, a unique G protein-coupled receptor for lysophosphatidic acid

31 citations , October 2010 in “Progress in lipid research”

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

research The role of lysophosphatidic acid in the physiology and pathology of the skin

24 citations , December 2018 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

research GC–MS profiling and in silico prediction of MAPK receptor activation by fatty acids of watercress oil for hair growth marketed in Saudi Arabia

5 citations , January 2021 in “Journal of Saudi Chemical Society”

Watercress oil may promote hair growth by activating specific receptors.

research Progress in the design of ascorbic acid derivative-mediated drug delivery

1 citations , January 2025 in “RSC Advances”

Ascorbic acid derivatives improve drug delivery systems.

research Assessing the Efficacy of Deoxycholic Acid for the Treatment of Submental Fat: A Three-Dimensional Study

7 citations , September 2018 in “Aesthetic surgery journal”

Deoxycholic acid effectively reduces double chin fat with temporary side effects and high patient satisfaction.

research Non-Edg family LPA receptors: the cutting edge of LPA research

68 citations , July 2011 in “Journal of Biochemistry/The journal of biochemistry”

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

research Lysophosphatidic acid increases the proliferation and migration of adipose-derived stem cells via the generation of reactive oxygen species

24 citations , July 2015 in “Molecular Medicine Reports”

Lysophosphatidic acid boosts stem cell growth and movement by creating reactive oxygen species.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Lysophosphatidic acid and signaling in sensory neurons

20 citations , January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.

research Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6

1 citations , January 2025 in “Proceedings of the National Academy of Sciences”

LPAR6 has a unique way of binding and activating, which helps in designing treatments for hair loss and cancer.

Optimization and Characterization of Cuscuta Reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

research Optimization and Characterization of Cuscuta reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

15 citations , January 2022 in “Journal of Oleo Science”

Phytosomal nanocarriers can significantly increase the bioavailability of Cuscuta reflexa extract.

research Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

253 citations , April 2009 in “Journal of Biological Chemistry”

p2y5, now called LPA6, is a receptor important for human hair growth.

research Autotaxin–lysophosphatidic acid– LPA ₃ signaling at the embryo‐epithelial boundary controls decidualization pathways

44 citations , June 2017 in “The EMBO Journal”

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

research Integrated Transcriptomics and Metabolomics Analyses of Stress-Induced Murine Hair Follicle Growth Inhibition

4 citations , February 2022 in “Frontiers in molecular biosciences”

Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.

research Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin

January 2025 in “Cellular & Molecular Biology Letters”

Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.

Development and Characterization of Phyto-Vesicles of Beta-Sitosterol for the Treatment of Androgenetic Alopecia

research Development and characterization of phyto-vesicles of β-sitosterol for the treatment of androgenetic alopecia

14 citations , December 2011 in “Archives of Dermatological Research”

Phyto-vesicles of β-sitosterol may effectively treat hair loss.

Inhibitory Effects of Serenoa Repens on the Kinetics of Pig Prostatic Microsomal 5α-Reductase Activity

research Inhibitory Effects of Serenoa repens on the Kinetic of Pig Prostatic Microsomal 5α-Reductase Activity

12 citations , January 1998 in “Endocrine journal”

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

research Mesococktails and mesoproducts in aesthetic dermatology

11 citations , August 2020 in “Dermatologic therapy”

The document concludes that mesotherapy can be effective for skin and hair treatments, but more research is needed to confirm its safety and effectiveness.

research Mesotherapy

1 citations , October 2010 in “Series in cosmetic and laser therapy”

Mesotherapy is a minimally invasive treatment with potential benefits and risks, requiring standardized practices and further investigation.

research Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications

17 citations , June 2021 in “Molecules”

Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.