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research A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty

3 citations , October 2024 in “Advances in Therapy”

This phase 3 study evaluated the efficacy and safety of a 6-month prolonged release formulation of triptorelin in 66 Chinese children with central precocious puberty (CPP). The study found that after two doses of triptorelin pamoate 22.5 mg, administered on day 1 and month 6, all patients achieved luteinizing hormone (LH) suppression at month 6, with 98.5% maintaining suppression at month 12. The treatment effectively suppressed sex hormone levels to prepubertal levels, slowed the development of sexual characteristics, and reduced growth velocity. The mean bone age/chronological age ratio decreased, and no severe treatment-related adverse events were reported. The study supports the use of 6-monthly triptorelin as a viable treatment option for Chinese children with CPP, consistent with findings in non-Chinese populations.

research Doxazosin + finasteride in BPH with TPV ??? 25mL

February 2006 in “Inpharma Weekly”

research Discovery of novel 5α-reductase type II inhibitors by pharmacophore modelling, virtual screening, molecular docking and molecular dynamics simulations

5 citations , January 2014 in “Molecular Simulation”

A new compound may treat benign prostatic hyperplasia better than finasteride.

research PD23-01 INHIBITOR OF 5A-REDUCTASE TYPES II PROMOTES THE INFILTRATION OF CD8+T CELLS IN BPH TISSUES.

March 2014 in “The Journal of Urology”

Finasteride increases CD8+ T cells in BPH tissues.

research 5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives

26 citations , October 2011 in “International Journal of Biological Macromolecules”

Some newly made compounds are promising for treating enlarged prostate, hair loss, viruses, and prostate cancer, and might be better than current drugs.

research New product intros (finasteride/tadalafil (new combination); sutimlimab; human SARS-CoV-2 recombinant nanoparticle vaccine, adjuvanted with AS03; bupropion hydrochloride/dextromethorphan hydrobromide (new combination))

January 2022 in “Drugs of Today”

A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)

research A randomized placebo-controlled multicentre study to evaluate the safety and efficacy of finasteride for male chronic pelvic pain syndrome (category IIIA chronic nonbacterial prostatitis).

127 citations , May 2004 in “PubMed”

Finasteride may help some male chronic pelvic pain patients, but more research needed.

research Phospholipase A₂ inhibition as potential therapy for inflammatory skin diseases

13 citations , April 2013 in “Immunotherapy”

Inhibiting PLA2 enzymes may help treat inflammatory skin diseases like psoriasis and dermatitis.

Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat

research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.

22 citations , October 2001 in “Biochemical Pharmacology”

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Effects of the Anti-Androgen Finasteride on 5α-Reduction of Androgens in the Presence of Progesterone in Human Gingival Fibroblasts: Modulatory Actions of the Alkaline Phosphatase Inhibitor Levamisole

research Effects of the anti-androgen finasteride on 5α-reduction of androgens in the presence of progesterone in human gingival fibroblasts: modulatory actions of the alkaline phosphatase inhibitor levamisole

9 citations , August 2000 in “Journal of Periodontal Research”

Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

2 citations , April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)”

The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.

Antiexudative Effects of Finasteride and a New Pyrazolo[C]Pyridine Derivative GIZh-72 in Acetic Acid-Induced Experimental Peritonitis

research Antiexudative Effects of Finasteride and a New Pyrazolo[C]Pyridine Derivative GIZh-72 in Acetic Acid-Induced Experimental Peritonitis

February 2020 in “Bulletin of Experimental Biology and Medicine”

Finasteride and GIZh-72 reduce inflammation, with GIZh-72 being more effective.

research 42736 Safety Assessments in the Multinational Phase 3 THRIVE-AA1 Trial with CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata

September 2023 in “Journal of the American Academy of Dermatology”

CTP-543 is generally safe for treating alopecia areata.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

23 citations , July 2021 in “International Journal of Pharmaceutics”

New dissolving and implantable microneedle patches have been created for a long-lasting, non-invasive delivery of the drug finasteride.

Mechanisms of Disease: Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 as a Novel Treatment for Metabolic Syndrome

research Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

69 citations , December 2005 in “Nature Clinical Practice Endocrinology & Metabolism”

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

5alpha-Reductase Inhibitors Dampen L-DOPA-Induced Dyskinesia via Normalization of Dopamine D1-Receptor Signaling Pathway and D1-D3 Receptor Interaction

research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction

26 citations , September 2018 in “Neurobiology of Disease”

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

research Sustained delivery of finasteride by biodegradable system

April 2017 in “DR-NTU (Nanyang Technological University)”

A biodegradable system can deliver finasteride consistently, reducing the need for daily pills.

research Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors

17 citations , December 2015 in “Bioorganic & Medicinal Chemistry”

3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.

research Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.

90 citations , January 1989 in “PubMed”

research EFFECTS OF FESOTERODINE, A NOVEL ANTIMUSCARINIC, ALONE AND IN COMBINATION WITH AN α-RECEPTOR BLOCKER, DOXAZOSIN, ON BLADDER FUNCTION IN OBSTRUCTED RATS

1 citations , March 2009 in “The Journal of Urology”

Combination therapy with fesoterodine and doxazosin improves bladder function and delays BPH progression.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research America - A Diversity of Life Styles.

January 1975 in “NJEA Review”

The drug showed promise in treating renal cell carcinoma with manageable side effects.

research Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells

July 2024 in “International Journal of Molecular Sciences”

The inhibitor DPP can promote hair growth.

research Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia

184 citations , January 2000 in “European Urology”

Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men

7 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research Alfuzosin/finasteride

May 2023 in “Reactions Weekly”

research Alfuzosin/finasteride

January 2013 in “Reactions Weekly”

research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines

4 citations , August 2010 in “Acta Biologica Hungarica”

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

research Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways

30 citations , December 2021 in “Frontiers in Microbiology”

Cepharanthine effectively reduces Herpes Simplex Virus Type 1 by blocking certain cell pathways and promoting cell death.

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