9 citations
,
November 2017 in “Journal of Glaucoma” Latanoprost eye drops may cause skin depigmentation.
9 citations
,
September 2020 in “Journal of cosmetic dermatology” A woman developed vitiligo from repeated eyebrow microblading.
5 citations
,
August 2015 in “Sultan Qaboos University medical journal” Vitamin B12 deficiency can cause skin darkening and other symptoms, which improve with B12 supplements.
9 citations
,
July 2012 in “Dermatitis” Hair dye with para-phenylenediamine can cause skin depigmentation.
5 citations
,
January 2015 in “Skin appendage disorders” Colored hair-thickening fibers can help hide hair loss in some people with Epidermolysis Bullosa but may cause scalp irritation.
PmtHEE is a better model for studying pigmented skin because it includes melanocytes and shows improved cell differentiation.
March 2007 in “The FASEB Journal” Henna mixed with PPD can cause skin reactions, scarring, and a specific type of baldness, and needs more research to understand these effects.
Hair turning darker can be a sign of skin cancer.
16 citations
,
February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
39 citations
,
August 2005 in “Dermatologic surgery” Micropigmentation is a widely accepted tattooing technique for hiding cosmetic issues and medical uses, with permanent results and few side effects, but risks infection if not done with sterile tools.
November 2024 in “Karnataka Pediatric Journal”
2 citations
,
May 2023 in “Photobiomodulation, photomedicine, and laser surgery” Light therapy is effective and safe for treating skin color disorders like vitiligo and dark spots.
77 citations
,
August 1986 in “Archives of Dermatology” Vitamin B12 deficiency can cause skin and hair color changes, which are reversible with treatment.
94 citations
,
October 2017 in “International Journal of Dermatology” Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.
24 citations
,
September 2008 in “Clinical and experimental dermatology” Repigmentation in vitiligo may come from melanocyte stem cells in the skin.
17 citations
,
April 2002 in “Contact Dermatitis” Minoxidil 5% caused skin discoloration in a man using it for hair loss.
1 citations
,
April 2015 in “Neurology” Skin pigmentation increases in CRPS-affected areas and improves with symptom relief.
21 citations
,
January 2007 in “Journal of the European Academy of Dermatology and Venereology” Travoprost can help eyelash growth but may cause darkening around the eyes.
31 citations
,
February 1999 in “Dermatologic surgery” Sun exposure after laser hair removal can cause skin darkening, which is hard to treat and requires avoiding UV light.
12 citations
,
January 2013 in “Indian dermatology online journal” Dermatopathia pigmentosa reticularis causes skin discoloration, hair loss, and nail problems.
February 2023 in “Indian journal of private psychiatry/Indian Journal of Private Psychiatry” Valproic acid can rarely cause reversible nail discoloration.
16 citations
,
January 2008 in “Acta dermato-venereologica” Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.
138 citations
,
June 2023 in “Molecules” Skin pigmentation varies due to genetics, UV exposure, and drugs, with treatments available but requiring medical advice.
March 2024 in “Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān/Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān./Zahedan journal of researches in medical sciences” Microneedling with PRP effectively reduces facial pigmentation with minimal side effects.
September 2017 in “Journal of Investigative Dermatology” Photodynamic therapy can potentially remove nonpigmented hair by damaging hair follicles.
March 2026 in “Indian Dermatology Online Journal” Hair dye ingredient PPD can cause severe allergic reactions, including facial swelling.
July 2025 in “Dermatology Practical & Conceptual” Topical eyedrops may cause eyelash whitening and skin lightening around the eyes.
1 citations
,
March 2022 in “Journal of burn care & research” Eyebrow tinting can cause chemical burns and increased awareness of its risks is needed.
14 citations
,
January 2018 in “Skin Appendage Disorders” Upper eyelid hyperpigmentation can help diagnose facial lichen planus pigmentosus in patients with frontal fibrosing alopecia.
October 2019 in “International journal of research in dermatology” Misusing topical corticosteroids can cause skin darkening and other side effects.