212 citations
,
May 2012 in “Genes & Development” Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.
92 citations
,
April 2009 in “Journal of Investigative Dermatology” The Celsr1 gene is crucial for normal hair patterning in mice.
33 citations
,
June 2017 in “Developmental Biology” Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.
29 citations
,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Loss of Fz6 disrupts hair follicle and associated structures' orientation.
24 citations
,
January 2018 in “Development” Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
19 citations
,
August 2012 in “Cell death and differentiation” Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.
8 citations
,
March 2022 in “Cancers” Proton minibeam radiotherapy may reduce skin side effects by causing localized DNA damage.
7 citations
,
January 2023 in “Frontiers in cell and developmental biology” Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.
2 citations
,
August 2023 in “Development” Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.
July 2025 in “Reproductive Biology” Finasteride use in male rats may harm their male offspring's liver function.
November 2024 in “Journal of Investigative Dermatology” Genetic defects in the Wnt/PCP pathway may cause congenital yellow nail syndrome.
June 2008 in “British Journal of Dermatology” UK medical students lack dermatology education, liver biopsy patients with risk factors show more fibrosis, and certain fungi resist drugs due to melanin; genetics may influence female hair loss.
July 2004 in “British Journal of Dermatology” The document concludes that accurate diagnosis and treatment are crucial in dermatology, and it presents various findings on skin conditions and treatments.
FoxA is crucial for planarian pharynx regeneration.
3 citations
,
February 2015 in “Scientific Research and Essays” The study showed that brown planaria can be used to cheaply test if local plants can stop cell growth.
FoxA is crucial for pharynx regeneration in planarian flatworms.
1 citations
,
October 2025 in “Journal of Visualized Experiments” The method creates skin organoids with hair follicles for research on skin conditions and treatments.
3 citations
,
March 2012 in “Actas Dermo-Sifiliográficas” An elderly man with skin amyloidosis and abnormal blood proteins was monitored without finding widespread disease after 18 months.
170 citations
,
November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.
56 citations
,
February 2013 in “International Journal of Molecular Medicine” Growth factors help hair follicle stem cells grow and stay versatile.
20 citations
,
December 2015 in “Journal of Pharmacopuncture” Thread-embedding therapy helped hair grow back in mice and might do the same in humans.
13 citations
,
December 2021 in “Wound repair and regeneration” Photobiomodulation helps hair regrow in injured skin by aiding cell movement and secretion.
13 citations
,
March 2021 in “British Journal of Pharmacology” KY19382 helps regrow hair and create new hair follicles.
13 citations
,
July 2020 in “Stem Cell Research & Therapy” Young donor, early passage stem cells have the highest stemness.
13 citations
,
July 2016 in “BMC Complementary and Alternative Medicine” Hominis Placenta helps hair grow back by increasing cell growth and a specific growth factor.
10 citations
,
July 2023 in “Pharmaceutics” Activating PKM2 and Wnt/β-catenin signaling speeds up wound healing.
10 citations
,
July 2019 in “Advances in Wound Care” Reducing Flightless I protein improves wound healing by activating skin stem cells.
9 citations
,
March 2009 in “European Journal of Dermatology” Schisandra nigra extract may help hair grow by stimulating cells and preventing hair follicle damage.
8 citations
,
February 2017 in “Archives of Dermatological Research” Intense pulsed light treatment effectively reduces underarm hair by making hair follicles smaller and extending their resting phase.
7 citations
,
October 2022 in “Development” Overactive Wnt5a disrupts hair follicle orientation in mice.