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GlossaryPotassium Channels

specialized proteins that regulate potassium ion flow in cells

Potassium channels are specialized proteins found in the cell membrane that allow potassium ions (K+) to pass in and out of the cell. They play a crucial role in maintaining the cell's electrical balance and are essential for various physiological processes, including nerve signal transmission, muscle contraction, and heart function. These channels are highly selective, ensuring that only potassium ions can pass through, which helps regulate the cell's internal environment.

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Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK

research Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK

22 citations , February 2008 in “Journal of Neurochemistry”

Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.

research The ATP sensitive potassium channel (KATP) is a novel target for migraine drug development

13 citations , June 2023 in “Frontiers in Molecular Neuroscience”

Blocking the KATP channel may help treat migraines.

research Investigations into the roles of potassium channels in hair growth : studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches

November 2010 in “Bradford Scholars (University of Bradford)”

KATP channels are crucial for hair growth, and targeting them may lead to new hair loss treatments.

research The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

5 citations , September 2022 in “Molecular pharmacology”

KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.

Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil

research Human hair follicles contain two forms of ATP‐ sensitive potassium channels, only one of which is sensitive to minoxidil

102 citations , February 2008 in “The FASEB Journal”

One minoxidil-sensitive potassium channel exists in human hair follicles.

research 507 Trial to investigate the role of ATP-sensitive potassium channels (KATPc) in dermal papilla cells (DPCs)

November 2024 in “Journal of Investigative Dermatology”

ATP-sensitive potassium channels are important for hair growth.

The Role of ATP-Sensitive Inward Rectifier Potassium Channels in the Regulation of Reactive Oxygen Species in the Western Honey Bee, Apis Mellifera L.

research The Role of ATP-Sensitive Inward Rectifier Potassium Channels In The Regulation of Reactive Oxygen Species In The Western Honey Bee, APIS Mellifera L.

June 2022

Activating certain potassium channels in honey bees can lower antioxidant levels and reduce death rates during heavy mite infestations, potentially aiding their immune response.

research Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol–response curve in porcine detrusor muscle

3 citations , March 2012 in “Arab Journal of Urology”

Certain drugs can reduce bladder muscle contractions, potentially helping treat bladder diseases.

research Novel and established potassium channel openers stimulate hair growth in vitromodes of action in hair follicles.: implications for their

January 2005

Potassium channel openers like minoxidil boost hair growth.

Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

research Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease interactions

3 citations , April 2023 in “Frontiers in Pharmacology”

ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

research Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice

9 citations , June 2017 in “Pharmacological Reports”

ATP-sensitive potassium channels play a role in chloroquine-induced itch in mice.

research Comparison of the effects of the K+-channel openers cromakalim and minoxidil sulphate on vascular smooth muscle

33 citations , May 1991 in “British Journal of Pharmacology”

Cromakalim relaxes various blood vessels, while minoxidil sulphate is more selective; they likely act on different potassium channels.

Minoxidil Suppressed Mitochondrial Depolarization and Subsequent Neuronal Cell Death by Decreasing Intracellular Potassium Level

research Minoxidil suppressed mitochondrial depolarization and subsequent neuronal cell death by decreasing intracellular potassium level

January 2018 in “日本薬理学会年会要旨集 =”

Minoxidil may protect the brain from damage by preventing cell death and energy loss.

research KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema

18 citations , October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

KATP channel openers may cause peripheral edema by reducing lymphatic contractions and flow.

research The Possible Involvement of KATP Channels in Cholestatic Pruritus in Mice

July 2024 in “Research Square (Research Square)”

KATP channels may help reduce itching in liver disease.

research Cantú Syndrome Is Caused by Mutations in ABCC9

148 citations , May 2012 in “The American Journal of Human Genetics”

Cantú syndrome is caused by mutations in the ABCC9 gene.

research Elastogenesis Stimulation by Minoxidil or Nebivolol Reduces Premature Aging of the Aortic Wall in Diabetic Mice

April 2024

Minoxidil and nebivolol can help prevent aortic aging in diabetic mice.

research Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.

47 citations , October 1989 in “Circulation Research”

The study explains how minoxidil sulfate causes vasodilation in rabbits by opening potassium channels and inhibiting calcium channels.

Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat

19 citations , October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.

research Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth

17 citations , August 2012 in “Archives of Pharmacal Research”

Acankoreoside J from Acanthopanax koreanum may help promote hair growth.

research Acquired Generalized Hypertrichosis Due to Diazoxide

3 citations , February 2013 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

A 6-year-old boy developed excessive hair growth after taking diazoxide for low blood sugar.

research K _ATP Channels and Cardiovascular Disease

144 citations , March 2013 in “Circulation Research”

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

research Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231

68 citations , January 2013 in “BMC Pharmacology and Toxicology”

Glibenclamide slows breast cancer cell growth by stopping cell division.

research 2‐Deoxy‐d‐glucose enhances tonic inhibition through the neurosteroid‐mediated activation of extrasynaptic GABA_A receptors

44 citations , October 2016 in “Epilepsia”

2-DG reduces seizures by enhancing brain inhibition through specific receptor activation.

research Potassium channel openers: therapeutic potential in cardiology and medicine

25 citations , December 2001 in “Expert Opinion on Pharmacotherapy”

Potassium channel openers show promise for treating heart disease and other conditions, but more research is needed to fully understand their effects and safety.

research Potassium channel openers: pharmacological and clinical aspects

119 citations , October 1992 in “Fundamental & Clinical Pharmacology”

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers?

research Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?

6 citations , April 2014 in “European journal of medicinal chemistry”

New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.

research Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells

16 citations , July 1994 in “Journal of Dermatological Science”

Minoxidil sulfate and pinacidil may promote hair growth through increased blood flow, not by activating potassium channels.

Potassium Channel Therapeutics at the Bedside

research K channel therapeutics at the bedside

119 citations , June 2005 in “Journal of Molecular and Cellular Cardiology”

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

research Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the BN Rat

28 citations , August 2013 in “Hypertension”

Potassium channel openers help form elastic fibers in arteries and can treat elastin deficiency and hypertension.