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GlossaryProlactin Receptor

protein on cell surfaces that binds to prolactin hormone

The Prolactin Receptor (PRLR) is a protein found on the surface of certain cells that binds to the hormone prolactin. This interaction is crucial for various biological processes, including lactation, reproductive functions, and immune system regulation. In the context of hair biology, prolactin and its receptor can influence hair growth and hair cycle regulation.

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research Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene

1 citations , February 2025 in “Journal of Dairy Science”

The SLICK1 allele in Holstein heifers affects hair and immune traits without altering prolactin signaling.

research Impact of mutations in PRLR for hair weight, circulating prolactin concentrations, feed intake, and growth of beef cattle in a hot and humid climate

July 2026 in “Frontiers in Endocrinology”

PRLR mutations affect cattle growth and hair weight in hot climates.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations , January 2003 in “Hormone Research in Paediatrics”

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Effects of Short Photoperiod on Cashmere Growth, Hormone Concentrations and Hair Follicle Development-Related Gene Expression in Cashmere Goats

research Effects of short photoperiod on cashmere growth, hormone concentrations and hair follicle development-related gene expression in cashmere goats

January 2023 in “Journal of applied animal research”

Short photoperiods improve cashmere growth and quality in goats by changing hormone levels and gene expression.

research Australian Hair and Wool Research Society Cutaneous Biology and Endocrinology Workshop

April 2003 in “Experimental Dermatology”

The workshop highlighted the genetic links and psychological impacts of hair loss and skin disorders.

research Molecular basis of androgen action on human sexual desire

12 citations , September 2017 in “Molecular and Cellular Endocrinology”

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

research Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?

26 citations , May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

research Effects of the bovine slick mutation on heat stress responses and hair growth in mice

January 2020

The mutation helps mice handle heat better without affecting hair growth.

Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro

research Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro

37 citations , March 2010 in “British Journal of Dermatology”

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.

research Impact of One-Week Administration of Dihydrotestosterone in Rat Anterior Pituitary Gland

1 citations , October 2022 in “International journal of endocrinology”

Dihydrotestosterone changes some hormone-related gene expressions in rat pituitary glands but doesn't affect the estrous cycle.

research Expression of the RORα gene in Inner Mongolian cashmere goat hair follicles

7 citations , January 2015 in “Genetics and molecular research”

The RORα gene is active in different parts of cashmere goat hair follicles and may be influenced by melatonin, especially in December when hair growth changes.

research Role of estrogen receptor signaling in the control of the hair follicle cycle

January 2004

Estrogen and its receptors play a key role in hair growth, with differences between males and females.

research Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats

7 citations , March 2021 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

Blocking prolactin increases the activity of secondary hair follicles in cashmere goats.

research Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

40 citations , April 2014 in “Genes & Development”

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

research New frontiers in human hair follicle (neuro‐)endocrinology

August 2006 in “Experimental dermatology”

Human scalp hair follicles can produce and respond to several hormones, affecting hair growth and pigmentation.

research The prevention of benign prostatic hyperplasia (bph)

12 citations , December 2016 in “Medical Hypotheses”

A vaccine may prevent benign prostatic hyperplasia (BPH).

research Neuroendocrinology of the hair follicle: principles and clinical perspectives

98 citations , July 2014 in “Trends in Molecular Medicine”

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

91 citations , May 2003 in “American Journal of Pathology”

Prolactin affects hair growth cycles and can cause early hair follicle regression.

Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

research Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice*

73 citations , June 2001 in “Endocrinology”

Prolactin affects when mice shed and grow hair.

The Prolactin Receptor as a Therapeutic Target in Human Diseases: Exploring New Potential Indications

research The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications

38 citations , June 2015 in “Expert Opinion on Therapeutic Targets”

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

research Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

14 citations , June 2001 in “Endocrinology”

Prolactin affects when mice shed and grow hair.

A Variant of the Glucocorticoid Receptor Gene Is Not Associated with Adrenal Androgen Excess in Women with Polycystic Ovary Syndrome

research A variant of the glucocorticoid receptor gene is not associated with adrenal androgen excess in women with polycystic ovary syndrome

20 citations , December 2000 in “Fertility and Sterility”

The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.

research CAG polymorphism in the androgen receptor gene in women may be associated with nodulocystic acne

7 citations , January 2019 in “Postepy Dermatologii I Alergologii”

Certain gene variations might be linked to severe acne in women but not in men.

Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women

research Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women

3 citations , May 2018 in “Reproductive Sciences”

The drug BAY 1158061 is safe, well-tolerated, and shows potential for treating diseases related to prolactin.

research Polymorphism of Exon V of prolactin gene and its association with Cashmere traits in Changthangi Pashmina goats

October 2017 in “The Indian Journal of Animal Sciences”

The prolactin gene polymorphism doesn't affect cashmere quality in these goats.

A New Heterozygous Variant of c.1225_1227delTTC (p.Phe409del) in Insulin Receptor Gene Associated with Severe Insulin Resistance and Hyperandrogenemia in an Adolescent Female with Type A Severe Insulin Resistance Syndrome

research A New Heterozygous Variant of c.1225_1227delTTC (p.Phe409del) in Insulin Receptor Gene Associated with Severe Insulin Resistance and Hyperandrogenemia in an Adolescent Female with Type A Severe Insulin Resistance Syndrome

1 citations , November 2024 in “Diabetes Metabolic Syndrome and Obesity”

A specific gene variant is linked to severe insulin resistance and hormone imbalance in a teenage girl.