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The levonorgestrel implant increases free testosterone and lowers SHBG more than DMPA-IM and the copper IUD.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

mrp/plf-mRNA can indicate tumor-promoting effects in skin.

Targeting the MC-5-HT-HTR2A axis may help treat chronic itching.

5α-reduced neurosteroids may help regulate glial cell differentiation.

DHEA inhibits growth in both mouse and human melanoma cells but works differently in each.

Mutations at Val-889 and Arg-752 disrupt key interactions in androgen receptor dimerization.

Recombinant Filaggrin-2 microneedles effectively promote hair growth and repair in hair loss.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

PLA2R1 overexpression harms kidney cells by stopping their growth cycle.

Sphingosine 1-phosphate helps control mechanical pain.

Dipotassium glycyrrhizinate helps wounds heal faster, especially in the early stages.

The MAPK/ERK pathway is crucial in controlling cell growth and death in finasteride-induced hypospadias.

Some prostate cancers have gene changes that may affect treatment with certain drugs.

The E2 protein affects gene activity in hair follicles of mice.

Polymers increased skin permeation and stability of steroid hormones in liposomal formulations.

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.

Oral difelikefalin significantly reduces itch in notalgia paresthetica.

During late pregnancy in rats, hormonal changes increased certain GABAA receptors in specific brain cells.

Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Vepdegestrant may become the first FDA-approved PROTAC degrader, marking a new era in drug development.

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.

In late pregnancy, allopregnanolone reduces stress responses in rats by affecting brain chemicals.

Normal cells outcompete and remove mutant cells in the pancreas with the help of the EphA2 receptor.