Recombinant Filaggrin-2 Microneedles Reverse Androgenetic Alopecia by Rescuing Mitochondrial Dysfunction in Dermal Papilla Cells

    Ruxue Chang, Jiawei Hao, Zhuoying Huang, Xiaorui Zhang, Ziyi Li, Qihong Wu, Xun Tang, Yifang Li, Huan Xia, Jingxian Deng, Yan Yang, Yadong Huang
    TLDR Recombinant Filaggrin-2 microneedles effectively promote hair growth and repair in hair loss.
    This study demonstrates that recombinant Filaggrin-2 (rFLG2) delivered via hyaluronic acid microneedles (HA/MNs) effectively promotes hair follicle regeneration and mitigates damage in dermal papilla cells (DPCs) caused by dihydrotestosterone (DHT), a key factor in androgenetic alopecia (AGA). In a DHT-induced AGA mouse model, rFLG2@HA/MNs significantly increased hair follicle density and prolonged the anagen phase, outperforming minoxidil. The treatment also facilitated the regeneration of undamaged hair follicles and accelerated wound healing. Mechanistically, rFLG2 counteracted DHT-induced mitochondrial dysfunction in DPCs by activating the MAPK/Erk signaling pathway and rebalancing Bcl-2/Bax expression, highlighting its potential as a safe and efficient strategy for AGA treatment.
    Discuss this study in the Community →

    Research cited in this study

    34 / 34 results