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GlossaryProstaglandin Analogs

synthetic compounds mimicking prostaglandins, affecting hair growth

Prostaglandin Analogs are synthetic compounds that mimic the action of prostaglandins, which are naturally occurring substances in the body involved in various physiological processes, including inflammation and the regulation of blood flow. These analogs are commonly used in medical treatments, such as for glaucoma to reduce intraocular pressure and in some cases to promote hair growth, as they can influence hair follicle activity.

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research Addressing Androgenetic Alopecia-A Complex Disorder-with a Multilateral Treatment Strategy

1 citations , February 2017 in “MOJ bioequivalence & bioavailability”

Treating hair loss effectively may require a multi-sided approach, using different treatments together, and topical treatments could be more effective and safer than oral ones.

research Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review

9 citations , December 2020 in “Dermatologic Therapy”

Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.

research The efficacy of latanoprost in the treatment of alopecia areata of eyelashes and eyebrows

20 citations , November 2009 in “European Journal of Dermatology”

Latanoprost, a glaucoma treatment, was found ineffective in treating hair loss in eyebrows and eyelashes.

research An update on diagnosis and treatment of female pattern hair loss

4 citations , August 2013 in “Expert Review of Dermatology”

Updated treatments for female hair loss include minoxidil, antiandrogens, hair transplants, and light therapy.

research Promising alternative clinical uses of prostaglandin F2α analogs: Beyond the eyelashes

31 citations , January 2015 in “Journal of The American Academy of Dermatology”

Prostaglandin F2α analogs show promise for treating certain types of hair loss but need more research for other skin conditions.

Recent Progress in Prostaglandin F2α Ethanolamide (Prostamide F2α) Research and Therapeutics

research Recent Progress in Prostaglandin F₂_αEthanolamide (Prostamide F₂_α) Research and Therapeutics

43 citations , July 2013 in “Pharmacological reviews”

New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.

research Human Scalp Hair Follicles Express Prostaglandin E2 Lipid Mediator and Receptors For Pge2

September 2013

Human scalp hair follicles have PGE2 and its receptors, which might affect hair growth.

Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

research Does prostaglandin D₂ hold the cure to male pattern baldness?

57 citations , February 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

research Expression of NAD+dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle

11 citations , March 2008 in “Experimental Dermatology”

A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.

Simultaneous Determination of Androgens and Prostaglandins in Human Urine Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry

research Simultaneous determination of androgens and prostaglandins in human urine using ultra-high-performance liquid chromatography–tandem mass spectrometry

10 citations , January 2019 in “Journal of Chromatography B”

Researchers developed a reliable way to measure hormones in urine, showing that a baldness treatment doesn't change hormone levels.

Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

research Prostaglandin D ₂ Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44

68 citations , November 2012 in “Journal of Investigative Dermatology”

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

research Multi-therapies in androgenetic alopecia: review and clinical experiences

55 citations , July 2016 in “Dermatologic Therapy”

Multiple treatments work best for hair loss.

research Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride and Hair Transplantation

13 citations , January 2016 in “Journal of cosmetology & trichology”

Alternative treatments show promise for hair growth beyond traditional methods.

A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth

research A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth

30 citations , May 2018 in “Experimental Dermatology”

The conclusion is that future hair loss treatments should target the root causes of hair thinning, not just promote hair growth.

research Novel therapies for alopecia areata: The era of rational drug development

9 citations , December 2017 in “The Journal of Allergy and Clinical Immunology”

New targeted therapies for hair loss from alopecia areata show promise, with personalized treatment expected in the future.

A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

research A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia

81 citations , August 2011 in “Journal of The American Academy of Dermatology”

Latanoprost 0.1% may effectively treat hair loss.

Effect of Latanoprost on Hair Growth in the Bald Scalp of the Stump-Tailed Macaque: A Pilot Study

research Effect of Latanoprost on Hair Growth in the Bald Scalp of the Stump-tailed Macacque: A Pilot Study

33 citations , January 2002

Latanoprost, a glaucoma drug, showed potential for promoting hair growth in bald monkeys, especially at higher doses.

research Advances in Vitiligo Treatment

March 2026 in “International Journal of Dermatology Venereology and Leprosy Sciences”

Vitiligo treatment requires a personalized mix of therapies to restore skin color and improve life quality.

Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations , June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research The prostamide‐related glaucoma therapy, bimatoprost, offers a novel approach for treating scalp alopecias

53 citations , October 2012 in “The FASEB Journal”

Bimatoprost, a glaucoma medication, may also help treat hair loss.

research Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia

38 citations , March 2017 in “Expert Opinion on Investigational Drugs”

Bimatoprost is promising for treating some types of hair loss but needs more testing for androgenetic alopecia.

research Eyelash Growth from Application of Bimatoprost in Gel Suspension to the Base of the Eyelashes

29 citations , May 2010 in “Ophthalmology”

Bimatoprost gel makes eyelashes grow longer, but may cause side effects and should be monitored by an eye doctor.

research The RELIEF study: Tolerability and efficacy of preservative-free latanoprost in the treatment of glaucoma or ocular hypertension

22 citations , March 2019 in “European Journal of Ophthalmology”

Preservative-free latanoprost effectively lowers eye pressure with fewer side effects.