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Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

research Experimental Evaluation of 3-meta-Pyridine-1,2,4-Oxadiazole Derivative of Deoxycholic Acid as a Prototype of 5-α-Reductase Inhibitors in In Silico and In Vivo Models

1 citations , February 2023 in “Russian Journal of Bioorganic Chemistry”

The new compound may be a safer alternative to finasteride for prostate protection.

research Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation

12 citations , June 2019 in “Psychoneuroendocrinology”

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

research PNU 157706, a novel dual type I and II5α-reductase inhibitor

42 citations , February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

research TMPRSS2, required for SARS-CoV-2 entry, is downregulated in lung cells by enzalutamide, a prostate cancer therapeutic

2 citations , June 2020 in “Research Square (Research Square)”

A prostate cancer drug can lower the levels of a protein that the coronavirus uses to enter lung cells.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Protein-phosphatase inhibitors block root hair growth and alter cortical cell shape of Arabidopsis roots

61 citations , December 1994 in “Planta”

research Nanoliposomal Co-Delivery of AR-PROTAC and NFKBIZ siRNA for Synergistic Therapy of Androgenetic Alopecia

January 2026 in “ACS Applied Bio Materials”

A new treatment using nanoliposomes can improve hair regrowth in androgenetic alopecia.

research Bioactive peptides derived from food proteins preventing lifestyle‐related diseases

223 citations , January 2000 in “BioFactors”

Food-derived peptides may help prevent diseases like high blood pressure and high cholesterol, and can support the immune system.

research Inhibiting Biosynthesis and/or Metabolism of Progestins in the Ventral Tegmental Area Attenuates Lordosis of Rats in Behavioural Oestrus

36 citations , July 2005 in “Journal of Neuroendocrinology”

Blocking certain brain processes reduces mating behavior in female rats.

research Androgens inhibit phagocytosis by macrophages via the androgen receptor in vitro

May 2026

Male hormones can decrease the ability of immune cells to fight bacteria.

research Slow progress in prostate cancer

February 2007 in “BJUI”

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

research Protein Kinase C as a Therapeutic Target

87 citations , September 2006 in “Clinical Cancer Research”

Protein Kinase C shows promise for cancer treatment, but more research is needed to develop effective inhibitors.

research 307 Dermatologic toxicities associated with chronic gamma-secretase inhibitor treatment for desmoid tumor

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.

research Docking and Molecular Dynamics Identify Leads against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment

10 citations , March 2023 in “Journal of Chemistry”

New compounds show promise for treating benign prostate hyperplasia with fewer side effects.

research Enzyme Inhibitors from Gorgonians and Soft Corals

4 citations , January 2023 in “Marine Drugs”

Marine compounds from gorgonians and soft corals show promise for drug development, especially for chronic disorders.

research Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia

184 citations , January 2000 in “European Urology”

Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.

Mechanisms of Disease: Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 as a Novel Treatment for Metabolic Syndrome

research Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

69 citations , December 2005 in “Nature Clinical Practice Endocrinology & Metabolism”

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

research Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

4 citations , December 2024 in “European Journal of Medicinal Chemistry”

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations , June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway

3 citations , October 2024 in “Frontiers in Pharmacology”

Compounds from Pterocarpus indicus may help treat benign prostatic hyperplasia by stopping cell growth.

research Review: Adding α₁-blockers to 5α-reductase inhibitors improves lower urinary tract symptoms in men

March 2014 in “Annals of Internal Medicine”

Combining α1-blockers with 5α-reductase inhibitors improves urinary symptoms in men.

research Selective inhibition of glucuronidation and sulfation in vitro and in vivo

1 citations , July 1990 in “European Journal of Pharmacology”

research In-silico analysis of papain fibrinolytic mechanism from Carica papaya

June 2025 in “Asia-Pacific Journal of Molecular Biology and Biotechnology”

Papain from papaya may help treat cardiovascular diseases by breaking down fibrin.

research Design, synthesis and anti-tumor evaluation of novel thiohydantoin congeners as androgen receptor antagonists with in vivo study.

May 2024 in “Journal of molecular structure”

A new compound, 3a, effectively fights prostate cancer better than finasteride.

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