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Did you mean Protein Kinase C?

GlossaryProtein Kinase C

enzymes that regulate various cellular functions by phosphorylating proteins

Protein Kinase C (PKC) is a family of enzymes that play a crucial role in several cellular processes, including cell growth, differentiation, and apoptosis (programmed cell death). These enzymes are activated by signals such as increases in the concentration of calcium ions or diacylglycerol (DAG), and they function by phosphorylating various target proteins, thereby altering their activity. PKC is significant in many physiological and pathological processes, making it a key focus in research related to cancer, cardiovascular diseases, and neurological disorders.

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research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

26 citations , June 2003 in “PubMed”

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.

research Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

28 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

research Induction of hair growth by skin irritants and its relation to skin protein kinase C isoforms

10 citations , April 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Skin irritants can promote hair growth by affecting specific skin proteins.

research Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism^¶

3 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may promote skin cancer development after UV exposure by affecting nearby cells.

research Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids

11 citations , January 2016 in “Molecular and Cellular Neuroscience”

Chronic ethanol increases certain brain receptor levels, influenced by steroids and protein changes.

research 측백엽(側柏葉) 추출물의 발모효과(發毛效果)에 관한 실험적 연구

January 2007 in “동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine”

Biotae Orientalis extracts may help treat hair loss.

research Androgen-induced norepinephrine release in male accessory sex organ smooth muscle growth and differentiation

October 2019

Androgens increase norepinephrine release, promoting smooth muscle growth in male sex organs, which may contribute to benign prostatic hypertrophy.

research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

research Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells

45 citations , September 2001 in “Journal of Investigative Dermatology”

Cyclosporin A promotes hair cell growth and affects protein kinase C levels.

Protein Kinase C Epsilon, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

research Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

10 citations , January 2013 in “Journal of skin cancer”

PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.

research The Molecular Mechanism Underlying the Proliferating and Preconditioning Effect of Vitamin C on Adipose-Derived Stem Cells

42 citations , February 2014 in “Stem Cells and Development”

Vitamin C helps adipose-derived stem cells grow and may support hair growth.

research Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study

37 citations , January 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

Apple extract called procyanidin B-2 was found to greatly increase hair growth.

research Comparative analysis of stemness between dermal papilla cells and human dermalstem/progenitor cells

April 2025 in “Cellular and Molecular Biology”

Human dermal stem/progenitor cells can divide and differentiate more than hair follicle dermal papilla cells.

research Claudin Expression Modulations Reflect an Injury Response in the Murine Epidermis

9 citations , July 2007 in “Journal of Investigative Dermatology”

Claudin expression changes help the skin respond to injury.

research Regulation of Involucrin Gene Expression

138 citations , June 2004 in “Journal of Investigative Dermatology”

Involucrin gene expression is controlled by specific proteins and signaling pathways.

research Type XVII collagen coordinates proliferation in the interfollicular epidermis

124 citations , July 2017 in “eLife”

Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.

research Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes

5 citations , November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Wnt/β-catenin signaling is important for keeping skin cell attachment structures stable.

research Tackling chemotherapy-induced alopecia

5 citations , January 2012 in “International journal of trichology”

Chemotherapy-induced hair loss is a major concern, but various treatments show promise in preventing and reversing it.

research A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies

35 citations , October 2014 in “Wound Repair and Regeneration”

The model helps understand scar contraction and develop new treatments.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells

research Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

August 1994 in “Molecular Endocrinology”

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

research Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos

7 citations , September 2019 in “Journal of Cellular Physiology”

Akt2 protein is essential for normal cell division in early mouse embryos.

research C‐reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase‐mediated oxidative stress

24 citations , January 2012 in “Journal of Cellular Biochemistry”

C-reactive protein helps monocytes stick to blood vessel cells by causing oxidative stress.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

18 citations , October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

The G-Protein Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

research The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

Expression and Distribution of the Guanine Nucleotide-Binding Protein Subunit Alpha-S in Mice Skin Tissues and Its Association with White and Black Coat Colors

research Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors

1 citations , January 2016 in “Asian-Australasian journal of animal sciences”

The protein GnÎ±s is found more in black mice than white mice and may influence their coat color.

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

research Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

3 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

Vitexin Compound 1 may help reduce skin aging caused by UVA light.