research Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk
A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.
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research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells
Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
research Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils
The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.
research Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda minima
CMX from Centipeda minima can significantly improve hair growth in mild to moderate balding.
research Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis
Bikunin is found on the cell boundaries of certain skin layers and may help regulate skin and hair functions.
research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Adding a second method to PROTACs could improve cancer treatment.
research An accessible pharmacodynamic transcriptional biomarker for notch target engagement
Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.
research Regarding prostate-specific antigen: let's not shoot the messenger
The drugs finasteride and dutasteride reduce low-grade prostate cancers but may double the risk of high-grade cancers.
research Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture
Mechanical forces are crucial for shaping cells and forming tissues during development.
research Androgen Receptor Ligands: Agonists and Antagonists
Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.
research NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
research Identification of Telogen Markers Underscores that Telogen Is Far from a Quiescent Hair Cycle Phase
Telogen is an active phase with important biological processes, not a resting phase.
research Localization of Cathepsins B, D, L, LAMP-1 and .MU.-Calpain in Developing Hair Follicles.
Lysosomal proteases and cytoplasmic enzymes help hair follicle cells develop and differentiate.
research Wound Healing: A Cellular Perspective
The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
research Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia
Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.
research Roles of tumor suppressors in regulating tumor-associated inflammation
Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.
research Are sex discordant outcomes in COVID-19 related to sex hormones?
Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.
research Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation
PAI-2 helps in the maturation and protection of hair and nail cells.
research Immune cell regulation of the hair cycle
Immune cells affect hair growth and could lead to new hair loss treatments.
research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.
research Nagashima-Type Palmoplantar Keratosis: A Common Asian Type Caused by SERPINB7 Protease Inhibitor Deficiency
Nagashima-type palmoplantar keratosis in Asians is caused by a SERPINB7 gene mutation.
research Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle
MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
research Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract
Blocking enzymes that help the virus enter cells could be a promising way to treat COVID-19.
research Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin
Rapamycin may help treat Leigh syndrome by targeting protein kinase C.
research Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model
Researchers found that hair shedding happens mostly when new hair is growing and involves a unique process.
research The PDGF/PDGFR pathway as a drug target
The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.
research Molecular basis of hair cell loss
The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.
research 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α
17β-Estradiol slows wound healing in male mice through estrogen receptor-α.
research Intramembrane Proteolysis of Astrotactins
Astrotactin-2 is cleaved in a specific way that helps understand its maturation.
research HIF‐2α/ARNT complex regulates hair development via induction of p21 Waf1/Cip1 and p27 Kip1
The HIF-2α/ARNT complex is important for hair follicle development by controlling cell growth.