April 2026 in “Future Medicinal Chemistry” Proteolysis-Targeting Chimeras (PROTACs) have significantly transformed drug discovery by utilizing a unique catalytic degradation mechanism that targets and degrades specific proteins. This technology has progressed from a laboratory concept to achieving clinical breakthroughs, demonstrating its potential in treating various diseases. PROTACs offer advantages over traditional inhibitors by providing sustained protein degradation, which can lead to more effective and durable therapeutic outcomes. The development of PROTACs has opened new avenues for targeting previously "undruggable" proteins, marking a pivotal advancement in the field of medicinal chemistry and pharmacology.
1 citations
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July 2024 in “Indian Journal of Case Reports” GAPO syndrome causes growth issues, hair loss, missing teeth, and vision problems.
32 citations
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August 2016 in “Science Signaling” Alopecia areata patients show unique protein activity patterns, suggesting imbalanced signaling pathways.
July 2024 in “Journal of Investigative Dermatology” Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.
September 2017 in “Journal of Investigative Dermatology Symposium Proceedings” Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.
October 2018 in “Dermatologic Surgery” October 2022 in “Amplla Editora eBooks” 
26 citations
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June 2018 in “The journal of immunology/The Journal of immunology” AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.
May 2018 in “Dermatologic Surgery” 
January 2026 in “Dermatology and Venerology” Complex therapy is more effective for long-term control of scalp abscesses.
56 citations
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March 2010 in “Journal of Dermatology” Most cases of Temporal Triangular Alopecia are found in early childhood and may be related to genetic conditions.
January 1999 in “Journal of the European Academy of Dermatology and Venereology” RAPK is a rare skin disorder with pigmented spots, mainly on hands and feet, starting in youth.
September 2017 in “ics.org” December 2025 in “Biomolecules” Targeting protein S-palmitoylation could lead to new skin disease treatments.
3 citations
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May 2015 in “Journal of The American Academy of Dermatology” Adalimumab significantly improves quality of life for patients with moderate to severe hidradenitis suppurativa.
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October 2009 in “Journal of the American Geriatrics Society” Finasteride may help reduce inappropriate sexual behaviors in dementia patients with prostate issues.
April 2026 in “Brain Sciences” Finasteride may cause depression and suicidal thoughts, especially in young men.
1 citations
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November 2025 in “Journal of Health Psychology” Alopecia Areata patients experience higher social appearance anxiety due to visible hair loss.
July 2022 in “Journal of Investigative Dermatology” TRPS1 loss in balding scalp areas contributes to hair loss in androgenic alopecia.
December 2024 in “Annals of Medicine and Surgery” Early diagnosis of pseudopelade of Brocq in men is crucial to prevent permanent hair loss.
October 2025 in “Journal of Cosmetic Dermatology” AOPT-MTL effectively and safely treats nasal blackheads in Asians.
January 2023 in “Editora Enterprising eBooks” Neuropsychopedagogy positively impacts education quality.
19 citations
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June 2018 in “Breast Cancer Research and Treatment” Scalp cooling effectively prevents severe hair loss in breast cancer patients treated with docetaxel and is safe.
17 citations
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April 1997 in “American Journal of Dermatopathology” PC-associated alopecia has unique microscopic features.
6 citations
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January 2018 in “Journal of Cellular Physiology” Human scalp fat stem cells showed improved cartilage-like development on a special scaffold with freeze-thaw treatment.
1 citations
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April 2016 in “Journal of Investigative Dermatology” Blocking Prostaglandin D₂ may help treat hair loss.
April 2024 in “Meždunarodnyj vestnik veterinarii” Deltsid 7.5 is the most effective treatment for bovine psoroptosis.
5 citations
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April 2024 in “JAAD International” AI can accurately measure hair loss severity in alopecia areata.
4 citations
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February 2001 in “PubMed” A medication called sodium valproate likely caused a girl's hair to become kinky and dry.
Careful diagnosis is crucial for premature pubarche, as 20% of cases have other conditions.