18 citations
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March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
5 citations
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January 2024 in “Reproductive Medicine and Biology” Androgen and Wnt signals are crucial for developing and functioning male genitalia and erectile tissues.
June 2013 in “Lithuanian University of Health Sciences” Hyperandrogenism does not affect young women's sexual function.
January 2008 in “Journal of Medicinal Chemistry” Finasteride may cause sexual and psychological side effects by affecting an enzyme related to epinephrine.
April 2017 in “Journal of Investigative Dermatology” Psoriasis patients experience moderate functional impairment related to disease severity and less satisfaction.
37 citations
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June 2011 in “Pediatrics in Review” Puberty is driven by hormonal changes, mainly influenced by genetics, nutrition, and body fat.
26 citations
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September 2005 in “Pharmacology Biochemistry and Behavior” 5alpha-reductase 2 is crucial for proper male brain development and sexual differentiation.
January 1983 in “Elsevier eBooks” Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by affecting androgen functions and suppressing certain hormones.
56 citations
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July 2001 in “International Journal of Clinical Pharmacology and Therapeutics” People obsessed with looking young may need therapy to address deeper issues.
Neurosteroids help control dopamine responses in the brain.
30 citations
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July 2009 in “Experimental and clinical endocrinology & diabetes” Cyproterone acetate effectively treats sexual disorders by reducing sexual functions and is generally well-tolerated.
18 citations
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September 1972 in “British Journal of Pharmacology” PCPA induces hypersexual behavior in male rats regardless of age or castration status.
25 citations
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September 2014 in “Pharmacotherapy” Hormone therapy can improve mental health and quality of life for people with gender dysphoria, but long-term effects need more research.
February 2023 in “Frontiers in Endocrinology” Too much male hormone in mothers can negatively affect the sexual behavior of both male and female baby mice.
1 citations
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October 2009 in “Current psychiatry” Choose treatments for sex offenders based on individual needs, using hormonal and nonhormonal options to reduce sexual drive.
58 citations
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April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology” Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.
41 citations
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March 1992 in “Archives of Dermatology” The review suggests that understanding and treating the psychological aspect of skin disorders is important and calls for more collaboration in this field.
49 citations
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September 2015 in “Psychoneuroendocrinology” 5α-reductase affects dopamine receptors linked to sensorimotor gating, which may help understand disorders like schizophrenia.
2 citations
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October 2016 in “European Neuropsychopharmacology”
35 citations
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November 2019 in “Frontiers in Neuroendocrinology” Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.
10 citations
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May 2018 in “Neuropharmacology” Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
January 2005 in “Dialnet (Universidad de la Rioja)” Post-SSRI sexual dysfunction syndrome was formally recognized in 2006, impacting clinical practice and research.
March 2024 in “The journal of sexual medicine” Finasteride's negative effects on brain tissue in male rats may be reversible after stopping the drug.
April 2009 in “Contemporary Psychoanalysis” Analysts should confront their biases and self-interests to improve therapy.
4 citations
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August 2021 in “Pediatrics in review” DSDs are birth conditions causing unusual sex development, managed with personalized care and sometimes surgery, but still lack a standard treatment approach.
72 citations
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January 2011 in “Current Pharmaceutical Design” S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
28 citations
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May 2015 in “Addiction Biology” Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.
January 2021 in “Deep Blue (University of Michigan)” Androgen receptors in the brain affect metabolism and reproduction differently in males and females, and may help manage PCOS symptoms in females.
2 citations
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April 2019 in “Journal of Internal Medicine” Men using steroids or finasteride to look more attractive may harm their fertility and sexual function, creating a paradox where they seem fit but may be less able to reproduce.
24 citations
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July 1983 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by blocking male sex hormones.