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The Drug Ontology was updated to better classify drugs for hypertension, malaria, and opioid abuse, and to allow for more accurate research queries.

Trichodynia is a painful scalp condition linked to hair loss and mental health issues, with limited treatment options.

Activating TRPV3 reduces skin oil production and increases inflammation, potentially causing dry skin issues.

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

Block and replace therapy improved symptoms in recurrent cyclic Cushing’s disease.

The skin produces and responds to thyroid-stimulating hormone, which is controlled by other thyroid-related hormones.

Activating TRPV3 stops human hair growth.

Using testosterone-stimulated weanling rats can effectively replace castrated rats for anti-androgen testing, reducing animal stress.

New treatments for male hypogonadism are effective and should be personalized.

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

PT-20 did not significantly improve gray hair repigmentation.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Neuropeptides affect hair growth and could be used to control it.

Intramuscular cyproterone acetate effectively treats hirsutism and improves skin conditions in women with hyperandrogenism.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by blocking male sex hormones.

Different types of PPARγ are found in varying amounts in human skin and its parts, which could affect how skin treatments work.

Topical peptides may offer safer, effective pain relief and healing for wounds.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Long-term treatment with buprenorphine/naloxone for opioid addiction may lead to secondary adrenal insufficiency.

Notopterygii rhizoma et radix (Qiang Huo) can effectively treat psoriasis by reducing skin symptoms and inflammation.

5-alpha-reductase inhibitors can effectively treat benign prostatic hyperplasia.

Polygoni Cuspidati Rhizoma et Radix contains compounds that inhibit certain enzymes.

A new compound, 3a, effectively fights prostate cancer better than finasteride.

Repeated use of platelet-rich plasma in rats caused increased pain sensitivity.

Krill oil may help reduce prostate enlargement and growth.

5ARIs effectively treat and manage BPH by reducing prostate size and symptoms.

Pulsatilla chinensis compounds may help prevent stress-related hair loss.

Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.