research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors
Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.
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research Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs
Nanoporous silica entrapped lipid-drug complexes significantly improve the solubility and absorption of drugs that don't dissolve well in water.
research Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.
research Drug repositioning: current approaches and their implications in the precision medicine era
Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.
research W6: Novelties in hair analysis and interpretation issues
Hair analysis can be unreliable due to external contamination and varying drug concentrations.
research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.
ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.
research Development and Validation of Spectrophotometric Method for Determination of Finasteride in Pharmaceutical Formulation Using 1,2-Naphthoquine-4-sulfonate (NQS)
New method accurately measures finasteride in medicine using NQS.
research Targeting telomeric RNA quadruplexes with natural metabolites to prevent cancer
research 560 The molecular mechanism of PCE-DP, a novel brightening active ingredient
PCE-DP brightens skin and promotes hair growth by enhancing cell growth and reducing melanin uptake.
research Determination of finasteride in healthy volunteers by optimized liquid chromatography-tandem spectrometry
The method accurately measures finasteride levels in the body.
research Folia Medica Cracoviensia
Polish doctors find performance-enhancing substances unethical and want more knowledge to combat doping in sports.
research Comparative study of the chemical profile, cytotoxic activity, and molecular docking of Serenoa repens extract and a pharmaceutical product
Serenoa repens extract shows promise as a natural treatment for prostate cancer.
research Distribution of the Quantum Dot Nano-particles that Penetrate Skin and Distinction of Combined Osmium Tetroxide in Electron Microscopic Analysis
Quantum dot nanoparticles can penetrate skin and reach sebocytes through hair follicles.
research Keratin
Understanding how keratin structures in hair are arranged and interact is key for creating methods to extract and purify them.
research Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents
Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.
research Search for New antineoplastic agents based on structural modifications of steroidal 5α-reductase, 17β-hydroxysteroid dehydrogenase, and 17α-hydroxylase/17,20-lyase inhibitors
Modifying steroidal inhibitors shows promise for developing new cancer treatments.
research Note on Isocholesterol, Coprosterol and the Classification of the Sterols
Isocholesterol is a confirmed and recognized sterol.
research Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.1)"
Reviewers criticized the study for assuming drugs with similar side-effects work the same way and questioned the validity of its findings due to potential biases and data quality issues.
research Exploring Nanotechnology With Traditional Herbal Pharmacology: Nano Carrier-Based Phytochemical Delivery In PCOS Treatment
Combining nanotechnology with herbal medicine may improve PCOS treatment.
research Simultaneous spectrophotometric determination of finasteride and tadalafil in recently FDA approved Entadfi™ capsules
The methods accurately measure finasteride and tadalafil in Entadfi™ capsules for quality control.
research Can you Create Low Molecular Weight Pharmacologically Active Substances and Maintain Mental Function Normal? Yes, we Can
New substances were created that improve health and may treat dementia, osteoporosis, and cancer.
research PC-SPES Studies Promising, But Manufacturer Shuts Down
Promising cancer treatments were found, but the manufacturer closed.
research Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches
Drug repositioning is a promising way to quickly develop new treatments, especially for rare diseases.
research 710 Use of mass spectrometry imaging and a full thickness 3D skin equivalent for evaluation of percutaneous absorption
The document concludes that various topical treatments show promise for skin conditions like atopic dermatitis, psoriasis, and hair loss.
research The effect of St John's Wort on the pharmacokinetics and metabolism of finasteride in healthy men
research Spray-Dried Rosuvastatin Nanoparticles for Promoting Hair Growth
research [Analysis of normal human hair keratins by two-dimensional polyacrylamide gel electrophoresis].
research Development and validation of a new gas flame ionization detector method for the determination of finasteride in tablets
New method accurately measures finasteride in tablets.
research Preparation of novel polymeric microspheres for controlled release of finasteride
PPCM microspheres allow controlled finasteride release over 24 hours.