Careful diagnosis is crucial for premature pubarche, as 20% of cases have other conditions.
40 citations
,
July 2016 in “Pediatrics in review” Puberty involves complex hormonal changes, varies by gender and ethnicity, and requires careful monitoring for abnormalities.
2 citations
,
January 1988 in “Deep Blue (University of Michigan)” Early puberty in girls leads to intense moods, restlessness, and greater self-certainty.
October 2025 in “Environment International” Exposure to certain chemicals before birth and during childhood may affect puberty timing.
October 2013 in “International Journal of Pediatric Endocrinology/International journal of pediatric endocrinology” A boy with early puberty and laughing seizures was treated, stopping seizures and slowing puberty.
November 2019 in “Monatsschrift Kinderheilkunde” The document concludes that pediatricians play a vital role in supporting adolescents through puberty and should enhance their competence in this area.
37 citations
,
June 2011 in “Pediatrics in Review” Puberty is driven by hormonal changes, mainly influenced by genetics, nutrition, and body fat.
29 citations
,
July 2011 in “Pediatrics in review” Accurate assessment of puberty using Tanner staging is crucial for identifying normal and abnormal development.
5 citations
,
February 2020 in “Journal of pediatric & adolescent gynecology” Recurrent vaginal bleeding in young girls without puberty signs may require a genital exam to find hidden causes.
192 citations
,
January 1976 in “The Journal of Clinical Endocrinology & Metabolism” Androgen levels increase with puberty and are linked to sexual hair development.
January 2026 in “Reproductive Toxicology” High coffee intake during pregnancy may cause earlier puberty in daughters.
169 citations
,
November 2009 in “The Journal of Clinical Endocrinology & Metabolism” Prepubertal girls have higher sex steroid levels than boys, possibly leading to earlier puberty.
30 citations
,
March 1980 in “European Journal of Endocrinology” Adrenal androgens are important for puberty and are influenced by genetics.
1 citations
,
November 2024 in “European Journal of Endocrinology” Higher childhood DHEAS levels are linked to advanced puberty and DNA changes.
19 citations
,
March 2004 in “The Journal of Clinical Endocrinology & Metabolism” Testosterone and letrozole treatment speeds up puberty in boys with delayed development.
8 citations
,
September 2020 in “Journal of adolescent health” Gender-affirming care for youth remained essential during the COVID-19 pandemic, with telemedicine playing a key role.
January 2023 in “Endocrine Journal” Treating classic 21-hydroxylase deficiency requires precise glucocorticoid dosing and attention to individual patient needs, with new treatments showing promise.
186 citations
,
February 1980 in “Clinical Endocrinology” During puberty, hormone levels rise, with early increases in some steroids and most menstrual cycles becoming regular by six years after menarche.
April 2020 in “Journal of the Endocrine Society” A 14-year-old girl with no menstrual period was diagnosed with Swyer Syndrome and treated for a related cancer risk.
21 citations
,
April 2010 in “Pediatrics in Review” Delayed puberty affects some teens, and early treatment with hormones can help improve their growth and social well-being.
15 citations
,
May 2010 in “Pediatrics in Review” Delayed puberty often runs in families, can affect growth, and may need hormone treatment.
March 1997 in “Journal of Endocrinology/Journal of endocrinology” Excessive hair growth in women can be treated with medications like spironolactone and finasteride, and male-pattern baldness in women can be improved with similar treatments.
95 citations
,
September 1979 in “Acta Paediatrica” Girls have higher DHEA levels earlier in puberty than boys, indicating earlier development.
20 citations
,
May 1998 in “PEDIATRICS” African-American girls tend to start puberty earlier than white girls, possibly due to increased androgen production.
17 citations
,
April 2009 in “Andrologia” A boy's early puberty caused by a testicular tumor returned to normal after surgery.
2 citations
,
April 2022 in “Annales d Endocrinologie” Recombinant gonadotropins improve future fertility in CHH patients.
2 citations
,
January 2000 in “Pediatrics in review” Early sexual development in children, especially girls, can be treated with hormone therapy to improve adult height and requires support for the child and family.
1 citations
,
May 2023 in “Fertility and sterility” Men who went through puberty later had lower sperm counts and altered hormone levels, possibly affecting fertility.
November 2022 in “Journal of the Endocrine Society” An 8-year-old boy's early puberty was caused by a rare hormone-secreting brain tumor, which was successfully treated with surgery.
May 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Hair can regrow in adult mice's skin after injury, and this process can be boosted by increasing Wnt7a, a protein. This could potentially help treat baldness and change our understanding of hair growth.