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Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata

research Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata

October 2025 in “Dermatology and Therapy”

Ritlecitinib is being tested for effectiveness and safety in treating severe alopecia areata.

research Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats

January 2023 in “Cutaneous and Ocular Toxicology”

research Distribution of SALT Scores with Ritlecitinib Treatment up to 24 months from the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata

November 2024 in “SKIN The Journal of Cutaneous Medicine”

Ritlecitinib effectively reduces severe hair loss in alopecia areata over 24 months.

research MYB30 and ETHYLENE INSENEITIVE3 antagonistically regulate root hair growth and phosphorus uptake under phosphate deficiency in Arabidopsis

16 citations , April 2021 in “Plant Signaling & Behavior”

MYB30 and EIN3 work against each other to control root hair growth and phosphorus uptake in plants when phosphate is low.

research Dicer- and BSC-dependent miRNAs during murine anagen development

1 citations , January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Dicer is crucial for hair growth in mice.

research Optimasi kombinasi ramuan etnomedisin penumbuh rambut Nusa Tenggara Timur menggunakan orthogonal stimulus response method pada berat rambut mencit (Mus musculus)

December 2025 in “eTheses of Maulana Malik Ibrahim State Islamic University (Maulana Malik Ibrahim State Islamic University)”

A traditional herbal mix from East Nusa Tenggara may help hair regrowth after chemotherapy.

research Purification and characterization of an immuno-stimulatory compound from the water extract of royoporus badius (Pers.) A.B. De.

January 2018

A new compound from Royoporus badius activates immune cells and induces inflammatory responses.

research Efficient Silencingof Androgen Receptor Gene viaUTR-Targeting siRNAs for Androgenetic Alopecia Therapy

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

AR-27 E-Chol siRNA can effectively promote hair regrowth for androgenetic alopecia.

research Patient Considerations when Using Ritlecitinib for Alopecia Areata in Adolescents: Guidance for the Clinicians

November 2024 in “Skin Appendage Disorders”

Clinicians should consider individual factors and communicate risks and benefits when prescribing ritlecitinib for adolescent alopecia areata.

research Patterns of clinical response in patients with alopecia areata treated with ritlecitinib in the ALLEGRO clinical development programme

13 citations , February 2025 in “Journal of the European Academy of Dermatology and Venereology”

Ritlecitinib shows promise for treating alopecia areata, especially with early and extended treatment.

research Rand Protease: The Role of Calcium-Binding Site on Stability with Mutagenesis and The Effectiveness on Leather Dehairing

December 2023 in “Sains Malaysiana”

The enzyme Rand protease works well for leather dehairing and its stability is important, with Leu75 playing a key role.

research Population exposure–response analysis of the effect of ritlecitinib on eyebrow assessment and eyelash assessment in patients with alopecia areata

1 citations , January 2025 in “CPT Pharmacometrics & Systems Pharmacology”

Ritlecitinib effectively regrows eyebrow and eyelash hair in alopecia areata, with 50 mg being the best dose.

research Cell surface receptor kinase FERONIA linked to nutrient sensor TORC signaling controls root hair growth at low temperature linked to low nitrate in Arabidopsis thalianai>

44 citations , January 2023 in “New Phytologist”

FER and TOR signaling help root hair growth in low temperature and low nitrate conditions.

research Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function
5 citations , August 2021 in “Journal of biological chemistry/The Journal of biological chemistry”

Retinoic acid affects male and female muscle energy use and function differently.

research Scalp, eyebrow, and eyelash hair regrowth with continued ritlecitinib treatment among patients with alopecia areata without target efficacy response at Week 24: post hoc analysis of the ALLEGRO phase 2b/3 study
July 2023 in “SKIN The Journal of Cutaneous Medicine”

Continued ritlecitinib treatment can improve hair regrowth in some alopecia areata patients who initially don't respond.

research El futuro incierto: etilogía de la crisis
January 1993 in “Claves de razón práctica”

ROR2 is crucial for hair follicle stem cell maintenance and self-renewal.

research Intragenic deletion in the Desmoglein 4 gene underlies the skin phenotype in the Iffa Credo “hairless” rat
28 citations , October 2004 in “Differentiation”

A gene deletion causes the "hairless" trait in Iffa Credo rats.

research Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice
2 citations , June 2023 in “Journal of cell science”

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

research Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial
227 citations , April 2023 in “The Lancet”

Ritlecitinib effectively treats alopecia areata and is well-tolerated.

research Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea
September 2022 in “Research Square (Research Square)”

Increasing Rps14 helps grow more inner ear cells and repair hearing cells in baby mice.

research Mechanism of action of NLRP3 protein macromolecule based on electrochemical sensors in the treatment of alopecia areata in mice: The role of Ritlecitinib in AA mice through NLRP3
March 2026 in “Microchemical Journal”

research Long-Term Efficacy and Complete Scalp Hair Regrowth in Patients With Alopecia Areata Receiving Ritlecitinib 50 mg QD Up to 3 Years in the ALLEGRO Clinical Trial Program
November 2025 in “SKIN The Journal of Cutaneous Medicine”

Ritlecitinib 50 mg effectively promotes and sustains hair regrowth in alopecia areata patients.

research Ritlecitinib: Efficacy of a Novel Therapy for Severe Alopecia Areata in Patients Aged 12 Years and Older
December 2025 in “Actas Dermo-Sifiliográficas”

Ritlecitinib is effective and safe for treating severe alopecia areata in people aged 12 and older.

research 17α-Acetoxy-6-bromo-16β-methylpregna-4,6-diene-3,20-dione
December 1998 in “Acta Crystallographica Section C-crystal Structure Communications”

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

research Efficacy and safety of ritlecitinib in Asian patients with alopecia areata: A subgroup analysis of the ALLEGRO phase 2b/3 trial
4 citations , March 2025 in “The Journal of Dermatology”

Ritlecitinib is effective and safe for hair regrowth in Asian patients with alopecia areata.

research A Plain Language Summary on Ritlecitinib Treatment for Adults and Adolescents with Alopecia Areata
7 citations , July 2023 in “Immunotherapy”

Ritlecitinib works well and is safe for treating alopecia areata.

research CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner
January 2024 in “Animals”

Circular RNA ERCC6 helps activate stem cells important for cashmere goat hair growth by interacting with specific molecules in an m6A modification-dependent way.

research Corrigendum: Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose
October 2024 in “Frontiers in Pharmacology”

The correction does not change the conclusion that 2-deoxy-D-ribose helps hair regrowth.

research Self-assembled polymeric nanocarriers for the targeted delivery of retinoic acid to the hair follicle
59 citations , January 2015 in “Nanoscale”

The new micelle formulation delivers acne treatment more effectively and safely than current gels.

research Barley disease susceptibility factor RACB acts in epidermal cell polarity and positioning of the nucleus
41 citations , April 2016 in “Journal of experimental botany”

RACB in barley is crucial for cell polarity and nucleus positioning, aiding fungal infection.

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