research Tissue engineering of skin and regenerative medicine for wound care
Current skin substitutes help heal severe burns but don't fully replicate natural skin features.
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540-570 / 1000+ resultsresearch The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis
mTOR inhibitors may help treat lung fibrosis.
research Matriptase: Potent Proteolysis on the Cell Surface
Matriptase is crucial for skin, hair, and immune cell health, and its imbalance can lead to cancer.
research Novel lysophosphoplipid receptors: their structure and function
Lysophospholipids can act as anti-inflammatory agents through specific receptors, but more research is needed.
research Fibroblast growth factors: key players in regeneration and tissue repair
Fibroblast Growth Factors (FGFs) are important for tissue repair and regeneration, influencing cell behavior and other factors involved in healing, and are crucial in processes like wound healing, bone repair, and hair growth.
research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.
Estrogen affects hair growth and skin cell multiplication.
research The Skin Microbiome: Current Landscape and Future Opportunities
The skin microbiome is crucial for skin health, and more research is needed to explore its role and potential treatments.
research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans
Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.
research Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases
Abnormal ECM and immune cell interactions can cause skin diseases.
research NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
NEDD4 and NEDD4L help control intestinal stem cells and prevent tumors by breaking down the LGR5 receptor.
research TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis
TCF/Lef1 activity is essential for proper skin cell development and renewal.
research Switching roles: the functional plasticity of adult tissue stem cells
Adult tissue stem cells can adapt and switch roles to help repair and maintain the body.
research Protein Kinase C as a Therapeutic Target
Protein Kinase C shows promise for cancer treatment, but more research is needed to develop effective inhibitors.
research Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus)
Primary and secondary hair follicle cells in Cashmere goats have different gene expressions affecting hair growth and size.
research Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures
A new 3D culture system helps grow and study mouse skin stem cells for a long time.
research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis
Inhibiting ODC can prevent UV-induced skin cancer.
research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice
Inhibiting ornithine decarboxylase may help prevent certain skin cancers.
research Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network
LGR5 mainly stays inside cells, moving to the trans-Golgi network, and this process is important for its role in cell signaling.
research Targeting integrin pathways: mechanisms and advances in therapy
New therapies are being developed that target integrin pathways to treat various diseases.
research The ophthalmological complications of targeted agents in cancer therapy: what do we need to know as ophthalmologists?
Cancer treatments can cause various eye problems, so eye doctors should know how to diagnose and treat these early.
research Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis
Too much Sonic Hedgehog protein stops hair growth in embryos.
research Immune-Epithelial Cross Talk in Regeneration and Repair
Immune-epithelial interactions are crucial for tissue repair, but unchecked can cause diseases.
research The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review
Higher ACE2 levels in certain tissues may worsen COVID-19 in people with other health issues, especially older adults.
research Sprouty/FGF signaling regulates the proximal–distal feather morphology and the size of dermal papillae
Sprouty and FGF balance is crucial for normal feather shape and size.
research Newly Developed Targeted Therapies Against the Androgen Receptor in Triple-Negative Breast Cancer: A Review
Targeting androgen receptors shows promise for treating triple-negative breast cancer, but more research is needed.
research Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Controlling cellular changes can enable safe rejuvenation without cancer risk.
research Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways
Noggin promotes skin tumors by activating certain cell signaling pathways.
research PROTACs: A novel strategy for cancer drug discovery and development
PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.
research Long and short non-coding RNA and radiation response: a review
Non-coding RNAs could help detect and treat radiation damage.
research Regeneration Genetics
Understanding tissue regeneration in animals can improve regenerative medicine.