This study identifies a distinct population of nail proximal fold stem cells (NPFSCs) that play a crucial role in nail growth and digit regeneration, with BMP signaling being a key regulator. Inhibition of BMP signaling led to limited regeneration, while its activation enhanced NPFSC involvement and significantly promoted digit regeneration, even allowing for full regeneration after substantial removal of the distal phalanx. The study also demonstrated that transplanted NPFSCs retained their regenerative capacity in vivo, suggesting their therapeutic potential. The findings highlight the importance of BMP-Wnt signaling cross-talk in mediating NPFSC-driven regeneration and offer a framework for improving regenerative outcomes after traumatic amputations.
April 2023 in “Journal of Investigative Dermatology” Skin cells and immune cells change in a skin condition called hidradenitis suppurativa, and a certain treatment can improve these changes.
1 citations
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April 2022 in “Journal of cosmetic dermatology” Krox20 overexpression in fibroblasts may play a role in abnormal scar formation and could be a target for new treatments.
10 citations
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January 2020 in “Journal of Materials Chemistry B” The biofilm enhances skin healing by promoting cell growth and blood vessel formation.
26 citations
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September 2018 in “Colloids and Surfaces B: Biointerfaces” A new liposome treatment helps heal deep burns on mice by improving hair regrowth and reducing scarring.
1279 citations
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November 2005 in “Nature Medicine” 27 citations
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July 2013 in “Journal of Investigative Dermatology” Revertant cell therapy shows promise for treating type XVII collagen deficiency, but better cell selection methods are needed.
63 citations
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May 2020 in “Advanced Healthcare Materials” The new wound dressing helps skin heal completely, including blood vessels and hair growth.
April 2025 in “ALEXMED ePosters” Combining nanofat with FUE improves scar appearance and function better than FUE alone.
1 citations
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February 2017 in “Dermatologic Surgery” The basement membrane matrix helps rebuild hair follicles faster and more effectively.
November 2022 in “Regenerative Therapy” Advancements in tissue engineering show promise for hair follicle regeneration to treat hair loss.
63 citations
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September 1987 in “Journal of Biological Chemistry” Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
4 citations
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January 2015 in “Experimental Dermatology” Human hair follicle dermal cells can help repair damaged hair follicles.
EDM is better for isolating and growing human foreskin fibroblasts, and PPP helps repair UVB damage.
3 citations
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June 2021 in “PLOS ONE” A topical BRAF inhibitor, vemurafenib, can speed up wound healing and promote hair growth, especially in diabetic patients.
9 citations
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August 2005 in “Archives of Dermatological Research” Scalp dermal papilla and fibrous sheath cells have different MMP expression than scalp dermal fibroblasts.
1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
January 2010 in “프로그램북(구 초록집)” Fgf9 helps create new hair follicles after injury through skin T cells.
April 2025 in “Frontiers in Bioengineering and Biotechnology” Gel-SHP helps skin heal faster.
February 2024 in “Skin research and technology” The research suggests that immune cells and a specific type of cell death called ferroptosis are involved in Frontal fibrosis alopecia.
16 citations
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March 2019 in “Experimental dermatology” Injury changes how hair follicle stem cells behave, depending on the hair growth stage.
5 citations
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April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” The gene therapy showed significant wound healing and was safe for treating severe RDEB.
69 citations
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October 2013 in “Journal of Tissue Engineering and Regenerative Medicine” Current skin repair methods for severe burns are inadequate, but stem cells and new materials show promise for better healing.
August 2025 in “Biomaterials” A new therapy using secretions from fetal cartilage cells shows promise for safe and effective hair regrowth.
February 2024 in “Research Square (Research Square)” Tiny particles from skin cells can help grow new hair by activating a specific growth signal during skin healing.
908 citations
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July 2015 in “British Journal of Dermatology” Acute wounds heal well, but chronic wounds struggle due to ongoing inflammation and poor tissue repair.
1 citations
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May 2023 in “PubMed” A certain type of skin cell, marked by EGFR, produces a lot of IGF1 and helps hair follicles grow back faster.
19 citations
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November 2012 in “Cell Communication and Signaling” FGF-9 speeds up the early development of certain organs, showing potential for organ regeneration.
135 citations
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December 2006 in “PLoS Medicine” Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.
March 2023 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)”