329 citations
,
January 1997 in “Journal of the American Academy of Dermatology” Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.
204 citations
,
February 2000 in “Current Medicinal Chemistry” Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.
202 citations
,
June 2005 in “Aaps Pharmscitech” Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.
169 citations
,
January 2018 in “Cell Reports” Scientists grew hair follicles from mouse stem cells in a lab setting.
146 citations
,
January 2004 in “Hormones” Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
144 citations
,
September 2012 in “Genes & development” Aging causes skin stem cells to work less effectively.
139 citations
,
August 2018 in “Development” The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.
133 citations
,
July 2020 in “Cells” Creating fully functional artificial skin for chronic wounds is still very challenging.
129 citations
,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
105 citations
,
April 2004 in “Dermatologic Therapy” The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.
99 citations
,
January 2014 in “Nature communications” Scientists created stem cells that can grow hair and skin.
96 citations
,
April 2007 in “Journal of Investigative Dermatology” Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.
86 citations
,
April 2009 in “Journal of anatomy” Hard skin features like scales, feathers, and hair evolved through specific protein changes in different animal groups.
75 citations
,
April 2000 in “Developmental Dynamics” Whn is essential for hair growth, and its malfunction causes hair loss.
73 citations
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August 2019 in “Cell Proliferation” Human skin models are essential for studying skin's sensory, immune, and nervous system interactions.
70 citations
,
August 2020 in “Nanomaterials” Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.
66 citations
,
June 2018 in “British Journal of Dermatology” European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.
66 citations
,
December 2014 in “Nature Communications” Fibroblasts can be turned into melanocytes for potential skin treatments.
54 citations
,
May 2001 in “Journal of Investigative Dermatology” Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.
50 citations
,
May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.
49 citations
,
June 2009 in “Seminars in Cutaneous Medicine and Surgery” The cosmetic industry should adapt to the varied beauty standards of ethnic groups and offer specialized treatments.
49 citations
,
February 2009 in “Maturitas” Short-term testosterone therapy in women seems safe with few mild side effects, but long-term effects need more research.
42 citations
,
January 2014 in “Cold Spring Harbor Perspectives in Medicine” Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.
41 citations
,
July 2019 in “Clinical Cosmetic and Investigational Dermatology” The skin's immune system helps it regenerate and fight infections.
37 citations
,
January 1997 in “Clinics in Dermatology” Hair problems are common and distressing for women, but increasing knowledge of treatments offers hope.
35 citations
,
August 2021 in “npj Regenerative Medicine” Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.
33 citations
,
October 2016 in “European Journal of Pharmaceutical Sciences” Effervescent formulations may improve minoxidil delivery, increasing effectiveness and reducing applications needed.
33 citations
,
November 2014 in “Military Medicine” The U.S. military's teledermatology program was effective in providing fast and successful skin care in remote locations, preventing unnecessary evacuations.
32 citations
,
September 2018 in “Journal of pharmaceutical sciences” The model better predicts how water-loving and fat-loving substances move through the skin by including tiny pores and hair follicle paths.
32 citations
,
January 2007 in “KARGER eBooks” Severe insulin resistance can be managed with medication, lifestyle changes, and treatment for related conditions.